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ClinicalTrials.gov public records Last synced Oct 23, 2026, 1:52 AM EDT

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Showing 793–816 of 1,007 matching trials from the local directory fallback.
Filters: Condition: Obesity Clear all
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation (Columbus)

NCT01911091
View directory record Official record
Conditions
Disorder of Lipid Storage and Metabolism, Lipid Metabolism Disorders, Metabolic Disorder, Obesity
Interventions
Exercise
Behavioral
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 40 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 14, 2026, 12:35 PM EDT
Active, not recruiting Not applicable Interventional

Program for Fully Understanding Eating and Lifestyle Change (FUEL)

NCT05562427
View directory record Official record
Conditions
Obesity
Interventions
Gold-Standard Online Behavioral Obesity Treatment
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Sep 20, 2026, 8:10 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Epigenetic Regulation of Human Adipose Tissue Distribution

NCT02728635
View directory record Official record
Conditions
Obesity
Interventions
Adipose tissue biopsies, Dual-energy X-ray absorptiometry (DEXA)/ Magnetic resonance imaging (MRI) and Magnetic resonance spectroscopy (MRS), FSIGTT/ RMR
Procedure · Other
Lead sponsor
AdventHealth Translational Research Institute
Other
Eligibility
18 Years to 45 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 27, 2026 · Synced Oct 17, 2026, 6:39 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Berries, Inflammation, and Gut Microbiome

NCT04100200
View directory record Official record
Conditions
Healthy, Overweight or Obesity
Interventions
Combination, Control, FOS, Mixed berries
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
20 Years to 60 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 23, 2026, 1:52 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Early vs. Late Time Restricted Eating vs. Daily Caloric Restriction

NCT05870982
View directory record Official record
Conditions
Overweight and Obesity
Interventions
DCR, Early TRE, Late TRE
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
162 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 14, 2026, 10:14 PM EDT
Active, not recruiting Phase 4 Interventional

Surgical or Medical Treatment

NCT04128995
View directory record Official record
Conditions
Bariatric Surgery Candidate, Diabetes Mellitus, Type 2, Pediatric Obesity
Interventions
Advanced Medical Therapy, Advanced Medical Therapy and Bariatric Surgery, Bariatric Surgery
Drug · Procedure
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
13 Years to 19 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
3
States / cities
Aurora, Colorado • Chicago, Illinois • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 16, 2026, 4:57 AM EDT
Active, not recruiting Phase 2 Interventional

A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity

NCT06037252
View directory record Official record
Conditions
Obesity, Type 2 Diabetes
Interventions
Placebo, Tirzepatide
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 75 Years
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
20
States / cities
Phoenix, Arizona • Concord, California • Sacramento, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 9, 2026, 8:01 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Engaging Men in Weight Loss With a Game-based mHealth and Neurotraining Program

NCT05408494
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Gamified behavioral weight loss treatment, mHealth behavioral weight loss treatment
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 65 Years
Enrollment
228 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 15, 2026, 8:05 AM EDT
Active, not recruiting Phase 2 Interventional

Taldefgrobep Alfa in Adults With Overweight and Obesity

NCT07281495
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Placebo, Taldefgrobep Alfa
Drug
Lead sponsor
Biohaven Therapeutics Ltd.
Industry
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
20
States / cities
Chula Vista, California • Montclair, California • Sacramento, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Jul 31, 2026, 6:34 AM EDT
Active, not recruiting Not applicable Interventional

Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia

NCT06998238
View directory record Official record
Conditions
Hyperandrogenemia, Insulin Resistance, Overweight and Obesity
Interventions
Mediterranean-based, carbohydrate restricted, calorie reduced diet
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
21 Years to 45 Years · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 3, 2026, 8:13 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)

NCT07180147
View directory record Official record
Conditions
Alzheimer Disease (AD), Cardio Vascular Disease, Disability Physical, Frailty Syndrome, Healthy Aging, Hypertension, Metabolic Syndrome (MetS), Mild Cognitive Impairment (MCI), Obesity &Amp; Overweight
Interventions
Not listed
Lead sponsor
Marymount University
Other
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2031
U.S. locations
1
States / cities
Arlington, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 17, 2026, 8:30 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Black Girls Move Physical Activity and Improving Dietary Intake Among Black Adolescent Daughters

NCT05433415
View directory record Official record
Conditions
Adolescent Obesity, Diabetes Mellitus
Interventions
Black Girls Move
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 16, 2026, 1:37 AM EDT
Active, not recruiting Phase 3 Interventional

A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity

NCT06859268
View directory record Official record
Conditions
Obesity
Interventions
Placebo, Retatrutide
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
643 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
33
States / cities
Santa Ana, California • Aurora, Colorado • Hamden, Connecticut + 30 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 15, 2026, 4:03 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide

NCT06484114
View directory record Official record
Conditions
Obesity, Weight Change Trajectory, Weight Change, Body
Interventions
Revita Duodenal Mucosal Resurfacing (DMR), Sham
Device
Lead sponsor
Fractyl Health Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
315 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
32
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Newport Beach, California + 24 more
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 15, 2026, 1:11 PM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity

NCT03318094
View directory record Official record
Conditions
Healthy, Insulin Resistance, Obesity
Interventions
Phentolamine, Saline, Sodium Nitroprusside
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2027
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 16, 2026, 7:09 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Reprometabolic Syndrome Mediates Subfertility in Obesity

NCT02653092
View directory record Official record
Conditions
Hyperinsulinemia, Hypogonadotropic Hypogonadotropism, Infertility, Obesity
Interventions
Dextrose, GnRH, Heparin, Hyperinsulinemic Euglycemic Clamp, Insulin, Intralipid
Drug · Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 38 Years · Female only
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 4, 2026, 8:04 PM EDT
Active, not recruiting Phase 3 Interventional

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

NCT06962280
View directory record Official record
Conditions
Obesity, Overweight, Type 1 Diabetes
Interventions
Placebo, Tirzepatide
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
465 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
18
States / cities
Bonita, California • Escondido, California • Newport Beach, California + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 15, 2026, 10:51 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Glucagon Suppression by Hyperglycemia in the Presence and Absence of Amino Acid Infusion

NCT05264727
View directory record Official record
Conditions
Healthy, Obesity, Type 2 Diabetes
Interventions
Clinisol 15%, Dextrose
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
25 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Jul 30, 2026, 1:34 AM EDT
Active, not recruiting Phase 2 Interventional

A Study of Setmelanotide in Patients With Prader-Willi Syndrome

NCT06772597
View directory record Official record
Conditions
Hyperphagia, Obesity, Prader-Willi Syndrome
Interventions
Setmelanotide
Drug
Lead sponsor
Rhythm Pharmaceuticals, Inc.
Industry
Eligibility
6 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 30, 2026, 8:15 PM EDT
Active, not recruiting Not applicable Interventional

Risk of Metabolic Adaptation After Weight Loss

NCT05139420
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
lifestyle intervention with meal replacement program
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 50 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Oct 18, 2026, 8:51 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Family Functioning in Obesity Treatment for Mexican Americans

NCT05120804
View directory record Official record
Conditions
Obesity
Interventions
Standard behavioral treatment, Standard behavioral treatment plus relationship skills training
Behavioral
Lead sponsor
Becky Marquez
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
2
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 30, 2026, 8:23 PM EDT
Active, not recruiting Not applicable Interventional

Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss

NCT03238794
View directory record Official record
Conditions
Obesity
Interventions
Low-calorie Diet, Roux-En-Y Gastric Bypass
Other · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 15, 2026, 8:48 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Piloting a Patient Navigator Program for Weight Loss

NCT06972381
View directory record Official record
Conditions
Obesity, Overweight
Interventions
Navigator
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jul 29, 2026, 3:26 AM EDT
Active, not recruiting Phase 2 Interventional

Safety and Efficacy of IMM01-STEM Against Placebo on Muscle Performance in Seniors With Obesity and Muscle Weakness

NCT06600581
View directory record Official record
Conditions
Muscle Performance, Sarcopenic Obesity
Interventions
IMM01-STEM, IMM01-STEM alternating with placebo (saline), Placebo
Biological · Other
Lead sponsor
Immunis, Inc.
Industry
Eligibility
60 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Garden Grove, California • Pomona, California • Lenexa, Kansas + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 7, 2026, 12:10 PM EDT