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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:52 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 25 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Osteoarthritic Knee Pain Clear all

Conditions: Osteoarthritis
Interventions: Dextrose Prolotherapy, Saline Prolotherapy, At-home physical therapy exercise group; Procedure · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 40 Years to 70 Years
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2016
U.S. locations: 2
States / cities: Madison, Wisconsin

Conditions: Osteoarthritis
Interventions: Buprenorphine transdermal patch, Placebo; Drug
Lead sponsor: Purdue Pharma LP; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 529 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 44
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 38 more

Conditions: Osteoarthritis
Interventions: naproxen, CE-224535, placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 212 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 46
States / cities: Anniston, Alabama • Bayou La Batre, Alabama • Birmingham, Alabama + 39 more

Conditions: Osteoarthritis, Knee Pain
Interventions: SL-1002, Placebo; Drug
Lead sponsor: Saol Therapeutics Inc; Industry
Eligibility: 35 Years and older
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 15
States / cities: Greenwood Village, Colorado • Washington D.C., District of Columbia • Coral Gables, Florida + 12 more

Conditions: Knee Osteoarthritis
Interventions: Corticosteroid injection; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 40 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
Interventions: Modular powered orthosis; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 85 Years
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Osteoarthritic Knee Pain
Interventions: Wireless neuromodulation; Device
Lead sponsor: Curonix LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 13
States / cities: Placentia, California • Denver, Colorado • Fort Lauderdale, Florida + 10 more

Conditions: Knee Osteoarthritis (Knee OA)
Interventions: genicular artery embolization, Corticosteroid Injection; Device · Drug
Lead sponsor: North American Science Associates Ltd.; Network
Eligibility: 40 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Osteoarthritis, Knee
Interventions: Amniotic Fluid, Saline Placebo; Other
Lead sponsor: MiMedx Group, Inc.; Industry
Eligibility: 30 Years and older
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 4
States / cities: Birmingham, Alabama • Atlanta, Georgia • Des Plaines, Illinois + 1 more

Conditions: Osteoarthritis, Knee
Interventions: XT-150; Biological
Lead sponsor: Xalud Therapeutics, Inc.; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Napa, California

Conditions: Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis in the Knee
Interventions: Anteromedial Injection, Anterolateral Injection; Procedure
Lead sponsor: University of Chicago; Other
Eligibility: 40 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 5
States / cities: Bolingbrook, Illinois • Chicago, Illinois • La Grange, Illinois + 2 more

Conditions: Osteoarthritis, Knee, Knee Pain Chronic
Interventions: 6% aqueous phenol, Isotonic saline; Drug
Lead sponsor: Kessler Foundation; Other
Eligibility: 40 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: West Orange, New Jersey

Conditions: Osteoarthritis, Knee
Interventions: PF-04136309, Placebo; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 159 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 18
States / cities: DeLand, Florida • South Miami, Florida • Overland Park, Kansas + 10 more

Conditions: Osteoarthritis, Knee
Interventions: StimRouter Neuromodulation System; Device
Lead sponsor: Bioventus LLC; Industry
Eligibility: 21 Years and older
Enrollment: 13 participants
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Livonia, Michigan

Conditions: Osteoarthritis
Interventions: Buprenorphine transdermal patch; Drug
Lead sponsor: Purdue Pharma LP; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 290 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 42
States / cities: Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 36 more

Conditions: Osteoarthritis
Interventions: Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts; Device
Lead sponsor: Rush University Medical Center; Other
Eligibility: 25 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Osteoarthritis, Knee
Interventions: Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit; Procedure · Device
Lead sponsor: Millennium Pain Center; Other
Eligibility: 18 Years to 100 Years
Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 3
States / cities: Bloomington, Illinois • Decatur, Illinois • Peoria, Illinois

Conditions: Osteoarthitis
Interventions: Cannabidiol (CBD), Castor Oil (Placebo); Dietary Supplement · Other
Lead sponsor: University of Tennessee; Other
Eligibility: 21 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Osteoarthritis of the Knee
Interventions: Cooled Radiofrequency, Standard Radiofrequency; Device
Lead sponsor: Avanos Medical; Other
Eligibility: 21 Years and older
Enrollment: 153 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 7
States / cities: Altoona, Pennsylvania • Sewickley, Pennsylvania • State College, Pennsylvania + 4 more

Conditions: Osteo Arthritis Knee
Interventions: Electrodermal Activity signal; Device
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 50 Years to 80 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Osteoarthritis
Interventions: Isometric exercise; Device
Lead sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); NIH
Eligibility: 18 Years and older
Enrollment: 92 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2002
U.S. locations: 6
States / cities: Trumbull, Connecticut • Moorestown, New Jersey • Rochester, New York + 3 more

Conditions: Osteoarthritis, Knee, Dementia
Interventions: Tai Chi, Attention control; Behavioral
Lead sponsor: University of Arkansas; Other
Eligibility: 60 Years and older
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Knee Osteoarthritis, Knee Pain Chronic, Knee Pain Swelling, Knee Arthritis, Arterial Occlusion
Interventions: Genicular artery embolization (GAE); Device
Lead sponsor: Andrew Picel; Other
Eligibility: 40 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Osteoarthritis, Knee, Pain
Interventions: CGS-200-1, CGS-200-5, CGS-200 Vehicle; Drug
Lead sponsor: Propella Therapeutics; Industry
Eligibility: 35 Years to 75 Years
Enrollment: 122 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 6
States / cities: Clearwater, Florida • Tampa, Florida • Cincinnati, Ohio + 2 more

Search by objective public record fields.

Joint Injections for Osteoarthritic Knee Pain

Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee

A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain

Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain

Do Knee Injections Offer Benefit With Knee Arthritis Pain

Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal

Freedom-1 Study for Chronic Knee Pain

Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain

Protocol for the Clinical Evaluation of Lyophilized Amniotic Fluid in the Treatment of Knee Osteoarthritis

Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee

Study of StimRouter for Chronic Knee OA Pain

Safety of BTDS in Subjects With Osteoarthritic (OA) Pain of Hip or Knee: A 6-Month Open-label Extension Phase

A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain

Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain

CBD Knee Osteoarthritis Study

Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain

Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals

Muscle Strengthening Device for Knee Osteoarthritis

Effect of Tai Chi on Osteoarthritic Knee Pain in Elders With Mild Dementia

Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain

A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control