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ClinicalTrials.gov public records Last synced Oct 3, 2026, 2:06 PM EDT

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Showing 25–48 of 62 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Transcatheter Aortic Valve Replacement (TAVR) Clear all
Active, not recruiting Not applicable Interventional

Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study

NCT05712161
View directory record Official record
Conditions
Aortic Stenosis, Symptomatic Aortic Stenosis, Severe Aortic Valve Stenosis, Aortic Valve Calcification
Interventions
DurAVRTM THV System
Device
Lead sponsor
Anteris Technologies Ltd.
Industry
Eligibility
65 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2033
U.S. locations
5
States / cities
Tucson, Arizona • Ann Arbor, Michigan • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Conduction Disease After Transcatheter Aortic Valve Replacement

NCT04489095
View directory record Official record
Conditions
Aortic Stenosis, Heart Block, Aortic Insufficiency
Interventions
Electrophysiology Study
Diagnostic Test
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 14, 2022 · Synced Oct 3, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

J-Valve Transfemoral Pivotal Study

NCT06455787
View directory record Official record
Conditions
Aortic Valve Regurgitation, Aortic Valve Disease Mixed
Interventions
J-Valve Transfemoral (TF) System
Device
Lead sponsor
JC Medical, Inc., an affiliate of Edwards Lifesciences LLC
Industry
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2032
U.S. locations
34
States / cities
Scottsdale, Arizona • La Jolla, California • Los Angeles, California + 26 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Completed No phase listed Observational Results available

Physical Therapy and Occupational Therapy After Transcatheter Aortic Valve Replacement

NCT03117296
View directory record Official record
Conditions
Transcatheter Aortic Valve Implantation
Interventions
Post procedure daily PT and OT, PT post procedure, OT post procedure, Routine PT or OT
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
Not listed
Enrollment
189 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 20, 2023 · Synced Oct 3, 2026, 2:06 PM EDT
Completed No phase listed Observational

Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement

NCT05614986
View directory record Official record
Conditions
Mild Cognitive Impairment, Aortic Stenosis
Interventions
5 minute Montreal Cognitive Assessment (mini MoCA)
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Dallas, Texas • Fort Worth, Texas • Plano, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

NCT05172973
View directory record Official record
Conditions
Aortic Valve Insufficiency, Aortic Valve Stenosis
Interventions
SAPIEN X4/X4S THV
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2039
U.S. locations
33
States / cities
Newport Beach, California • San Francisco, California • Stanford, California + 25 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Completed Not applicable Interventional

The PROTEMBO Trial

NCT05873816
View directory record Official record
Conditions
Severe Aortic Valve Stenosis
Interventions
ProtEmbo - Cerebral Embolic Protection, Sentinel - Cerebral Embolic Protection
Device
Lead sponsor
Protembis GmbH
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
15
States / cities
Tucson, Arizona • Los Angeles, California • Clearwater, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial

NCT06817148
View directory record Official record
Conditions
Aortic Valve Stenosis, Bicuspid Aortic Valve
Interventions
transcatheter aortic valve replacement (TAVR), surgical aortic valve replacement (SAVR)
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2037
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 3, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

Comparison of Single vs. Dual Perclose Devices for Large-Bore Access Closure in TAVR

NCT06871774
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement
Interventions
Single Perclose Pro vascular closure device, Dual Perclose vascular closure device
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Completed No phase listed Observational

Conduction Abnormalities With Severe Aortic Stenosis Before and After Transcatheter Aortic Valve Replacement

NCT03180073
View directory record Official record
Conditions
Bradycardia
Interventions
Ziopatch Pre discharge, Ziopatch at Discharge, Ziopatch at 2 months
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 3, 2026, 2:06 PM EDT
Terminated Phase 3 Interventional Results available

Global Study Comparing a rivAroxaban-based Antithrombotic Strategy to an antipLatelet-based Strategy After Transcatheter aortIc vaLve rEplacement to Optimize Clinical Outcomes

NCT02556203
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement
Interventions
Rivaroxaban (Xarelto, BAY59-7939), Acetylsalicylic Acid (ASA), Clopidogrel, Vitamin K antagonist (VKA)
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
1,653 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
31
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Clearwater, Florida + 27 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2020 · Synced Oct 3, 2026, 2:06 PM EDT
Withdrawn Not applicable Interventional

U.S. Multicenter Feasibility Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR

NCT06069661
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Aortic Stenosis
Device
Lead sponsor
EnCompass Technologies, Inc.
Industry
Eligibility
22 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Oct 3, 2026, 2:06 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

CT TAVR Abdomen Study

NCT05758701
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement
Interventions
Iodinated Contrast Agent (Omnipaque), Dual Energy CT
Combination Product · Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 88 Years
Enrollment
164 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Prehabilitation to Improve Functional and Clinical Outcomes in Patients With Aortic Stenosis

NCT02597985
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Prehabilitation, Usual Care
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 23, 2021 · Synced Oct 3, 2026, 2:06 PM EDT
Active, not recruiting Not applicable Interventional Results available

ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

NCT03735667
View directory record Official record
Conditions
Aortic Stenosis
Interventions
ACURATE neo2™ Transfemoral TAVR System, Medtronic CoreValve TAVR System, Edwards SAPIEN 3 TAVR System, ACURATE Prime™ Transfemoral TAVR System XL
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
Not listed
Enrollment
1,948 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2029
U.S. locations
69
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 58 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 3, 2026, 2:06 PM EDT
Completed Not applicable Interventional

Prehabilitation for Patients Undergoing Transcatheter Aortic Valve Replacement

NCT03107897
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Pre-habilitation
Other
Lead sponsor
WellSpan Health
Other
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 9, 2023 · Synced Oct 3, 2026, 2:06 PM EDT
Active, not recruiting No phase listed Observational

Acute Kidney Injury Genomics and Biomarkers in TAVR Study

NCT02791880
View directory record Official record
Conditions
Acute Kidney Injury, Renal Insufficiency, Chronic, Heart Failure, Myocardial Infarction, Arrhythmias, Cardiac, Stroke
Interventions
Transcatheter Aortic Valve Replacement
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2031
U.S. locations
3
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 3, 2026, 2:06 PM EDT
Completed Phase 2 Interventional

18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes

NCT03095313
View directory record Official record
Conditions
Aortic Stenosis
Interventions
18F-NaF
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Oct 3, 2026, 2:06 PM EDT
Recruiting Not applicable Interventional

MRI in Transcatheter Aortic Valve Replacement Patients

NCT05603026
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Self-expanding valve (Medtronic Evolut FX), Balloon-expanding valve (Edwards Sapien 3 Ultra RESILIA)
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 105 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 3, 2026, 2:06 PM EDT
Completed Phase 3 Interventional Results available

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)

NCT02833948
View directory record Official record
Conditions
Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Ventricular Outflow Obstruction, Thrombosis
Interventions
Acetylsalicylic acid, Clopidogrel, Rivaroxaban
Drug
Lead sponsor
ECRI bv
Industry
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Los Angeles, California • New York, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 3, 2026, 2:06 PM EDT
Terminated Not applicable Interventional Results available

Transmural Systems Transcaval Closure Device for Transcaval Access Ports During Transcatheter Aortic Valve Replacement

NCT03432494
View directory record Official record
Conditions
Aortic Stenosis
Interventions
Transcaval closure device (TCD)
Device
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Atlanta, Georgia • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 3, 2026, 2:06 PM EDT
Active, not recruiting Not applicable Interventional

Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study

NCT06680427
View directory record Official record
Conditions
Aortic Stenosis Symptomatic
Interventions
Siegel Transcatheter Aortic Valve (TAVR)
Device
Lead sponsor
MiRus
Industry
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
8
States / cities
Los Angeles, California • Palo Alto, California • Naples, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2025 · Synced Oct 3, 2026, 2:06 PM EDT
Withdrawn No phase listed Observational

Assessment of Neurologic Injury Subsequent to Transcatheter Aortic Valve Replacement: A Feasibility Study

NCT01927601
View directory record Official record
Conditions
Severe Symptomatic Aortic Stenosis
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Oct 3, 2026, 2:06 PM EDT
Active, not recruiting Not applicable Interventional

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

NCT02661451
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
SAPIEN 3 THV, Optimal Heart Failure Therapy
Device · Biological
Lead sponsor
Cardiovascular Research Foundation, New York
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
46
States / cities
Chandler, Arizona • La Jolla, California • Los Angeles, California + 37 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 3, 2026, 2:06 PM EDT