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Conditions: Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Sensation Disorders, Vision Disorder, Neurological Manifestations, Eye Diseases, Hereditary, Eye Diseases, Eye Disorders Congenital, Retinal Disease
Interventions: sepofarsen, Placebo IVT; Drug · Other
Lead sponsor: Laboratoires Thea; Industry
Eligibility: 6 Years and older
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 5
States / cities: San Francisco, California • Miami, Florida • Iowa City, Iowa + 2 more

Conditions: Myopia, Astigmatism
Interventions: Wavelight Plus LASIK; Device
Lead sponsor: Laser Defined Vision; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Greensboro, North Carolina

Conditions: Macular Edema, Retinal Vein Occlusion
Interventions: KSI-301, Aflibercept, Sham Procedure; Drug · Other
Lead sponsor: Kodiak Sciences Inc; Industry
Eligibility: 18 Years and older
Enrollment: 568 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 81
States / cities: Phoenix, Arizona • Beverly Hills, California • Fresno, California + 75 more

Conditions: Non-proliferative Diabetic Retinopathy
Interventions: KSI-301, Sham injection; Drug · Other
Lead sponsor: Kodiak Sciences Inc; Industry
Eligibility: 18 Years and older
Enrollment: 253 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 46
States / cities: Phoenix, Arizona • Beverly Hills, California • Fullerton, California + 42 more

Conditions: Metamorphopsia, Aniseikonia
Interventions: Aegenta VR; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Vision, Low, Blindness
Interventions: Interaction with Mock COVID-19 Rapid Antigen Test and Reference Surfaces, Biomechanical Measurements, Psychophysical Tasks; Diagnostic Test · Behavioral
Lead sponsor: University of Delaware; Other
Eligibility: 12 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 1
States / cities: Newark, Delaware

Conditions: Subacromial Impingement Syndrome, Apical Shoulder Pain, Rotator Cuff Syndrome
Interventions: Verbal and tactile feedback with exercise; Other
Lead sponsor: California State University, Long Beach; Other
Eligibility: 18 Years to 70 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Long Beach, California

Conditions: Presbyopia Correction, Presbyopia, Dysphotopsia, Visual Acuity
Interventions: TECNIS PureSee IOL (Model DEN00V/DET150), TECNIS Odyssey IOL (Model DRN00V/DRT150); Device
Lead sponsor: Dr. Daniel H. Chang, MD; Other
Eligibility: 22 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Bakersfield, California

Conditions: Visual Snow Syndrome, Migraine, Healthy
Interventions: Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Imaging (MRS); Behavioral · Device
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 60 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Sleep Disorder, Blindness
Interventions: Melatonin; Drug
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 5 Years to 20 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
Interventions: Local anesthetic; Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
Interventions: Glycerol Tributyrate; Drug
Lead sponsor: George Washington University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Obesity
Interventions: Visual feedback monitoring system (HFFS), Control; Device · Other
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 20 Years to 45 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Hattiesburg, Mississippi

Conditions: Amblyopia
Interventions: patching, Dichoptic videos; Other
Lead sponsor: Retina Foundation of the Southwest; Other
Eligibility: 3 Years to 7 Years
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Dry Eye Syndromes
Interventions: Cyclosporine 0.05% Ophthalmic Emulsion; Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 2
States / cities: Andover, Massachusetts • Memphis, Tennessee

Conditions: Diabetic Retinopathy
Interventions: Not listed
Lead sponsor: National Eye Institute (NEI); NIH
Eligibility: Not listed
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2000
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Stroke
Interventions: Visual ROM augmentation, Visual ROM reduction; Device
Lead sponsor: The Catholic University of America; Other
Eligibility: 20 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Neovascular Age-Related Macular Degeneration (nAMD), Wet AMD
Interventions: Ixo-vec, Aflibercept; Genetic · Drug
Lead sponsor: Adverum Biotechnologies, Inc.; Industry
Eligibility: 50 Years and older
Enrollment: 534 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 79
States / cities: Mesa, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 65 more

Conditions: Amblyopia
Interventions: Luminopia One; Device
Lead sponsor: Luminopia; Industry
Eligibility: 4 Years to 12 Years
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 9
States / cities: Maitland, Florida • Chicago, Illinois • Bloomington, Indiana + 6 more

Conditions: Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Non-infectious Panuveitis
Interventions: LFG316, Conventional Therapy; Drug
Lead sponsor: Novartis Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 6
States / cities: Golden, Colorado • Marietta, Georgia • Cambridge, Massachusetts + 3 more

Conditions: Glaucoma
Interventions: Brown Glaucoma Implant; Device
Lead sponsor: MicroOptx; Industry
Eligibility: 22 Years and older
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 3
States / cities: Bloomington, Minnesota • Dayton, Ohio • Dallas, Texas

Conditions: Cataract
Interventions: Tecnis Symfony OptiBlue/ Tecnis Symfony OptiBlue toric IOL; Device
Lead sponsor: Coastal Eye Surgeons PLLC; Other
Eligibility: 50 Years to 85 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Greenwich, Connecticut

Conditions: Cataract
Interventions: ReSTOR Toric; Device
Lead sponsor: Gainesville Eye Associates; Other
Eligibility: 30 Years and older
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Gainesville, Georgia

Conditions: Foot Injuries and Disorders, Ankle Injuries and Disorders, Achilles Tendon Injury
Interventions: medrol dosepak, HYDROcodone Oral Tablet; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 95 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Atlanta, Georgia • Johns Creek, Georgia

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Study to Evaluate Sepofarsen in Subjects With Leber Congenital Amaurosis (LCA) Type 10 (HYPERION)

Clinical Evaluation of WaveLight Plus LASIK

A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)

A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 in Non-proliferative Diabetic Retinopathy (NPDR)

Virtual Reality Aniseikonia and Metamorphopsia Testing

Validation of Texture Changing Coatings for Use in At-Home Rapid Tests

Comparison of Dynamic Ultrasound Visual Feedback to Manual Feedback on Scapular Stabilizer Activation and Change in the Subacromial Space in Persons With Pain During Shoulder Elevation

Clinical Evaluation of Visual Performance, Spectacle Independence, and Patient Satisfaction With TECNIS PureSee Mini-Monovision and TECNIS PureSee-TECNIS Odyssey Mix-Match

Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

Melatonin Studies of Totally Blind Children

Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment

A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)

Visual Feedback Monitoring During Exercise in Individuals With Obesity

Dichoptic Video Treatment for Amblyopia

Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis®

Long-Term Follow-Up of Patients Enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS)

Sensory Feedback and Hand Motor Adaptation

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

Luminopia One Pilot Study

Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis ,

Early Feasibility Study of the Brown Glaucoma Implant in Patients With Severe Visual Impairment or No Light Perceived

Visual Outcomes of Tecnis Symfony Opti-Blue EDOF Intraocular Lens (IOL)

Evaluating Refractive and Visual Outcomes With the Alcon Toric ReSTOR +2.5 and +3.0 Models

Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients