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ClinicalTrials.gov public records Last synced Sep 28, 2026, 10:14 AM EDT

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Showing 1–24 of 35 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Alteplase (iv t-PA) Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacogenetics of Ace Inhibitor-Associated Angioedema

NCT01413542
View directory record Official record
Conditions
Hypertension, Diabetes Type 2
Interventions
Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin, enalaprilat (ACE inhibitor), Glucagon-like peptide 1, brain natriuretic peptide
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Not applicable Interventional

IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of Major Vessel Occlusion

NCT00624000
View directory record Official record
Conditions
Ischemic Stroke
Interventions
IV tpa (Alteplase) vs IA tpa (Alteplase)
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
19 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2011 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 2 Interventional Results available

Safety of Rt-PA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery

NCT01220739
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Transcranial Laser Therapy
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
3
States / cities
Englewood, Colorado • Columbia, South Carolina • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Sep 28, 2026, 10:14 AM EDT
Withdrawn Phase 1 Interventional

Study for the Use of Alteplase in Patients Who Awaken With Stroke

NCT01150266
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Alteplase (tPA)
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
22 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 12, 2013 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 2 Interventional Results available

Randomized Controlled Trial of Argatroban With Tissue Plasminogen Activator (tPA) for Acute Stroke

NCT01464788
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Low Dose Argatroban, High Dose Argatroban, rt-PA (alteplase)
Drug
Lead sponsor
Andrew D. Barreto, MD
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 2 Interventional Results available

A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients

NCT01282242
View directory record Official record
Conditions
Acute Stroke
Interventions
IV rt-PA
Drug
Lead sponsor
Lee Schwamm
Other
Eligibility
18 Years to 85 Years
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
14
States / cities
Tucson, Arizona • Los Angeles, California • Chicago, Illinois + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2017 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 1 Interventional Results available

Thrombolysis in Pediatric Stroke (TIPS)

NCT01591096
View directory record Official record
Conditions
Stroke
Interventions
Tissue plasminogen activator (Activase®)
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
2 Years to 17 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
13
States / cities
Palo Alto, California • Aurora, Colorado • Boston, Massachusetts + 9 more
Source: ClinicalTrials.gov public record
Updated May 24, 2018 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 3 Interventional Results available

Interventional Management of Stroke (IMS) III Trial

NCT00359424
View directory record Official record
Conditions
Stroke
Interventions
IV rt-PA alone, endovascular therapy
Drug · Other
Lead sponsor
Joseph Broderick
Other
Eligibility
18 Years to 82 Years
Enrollment
656 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
49
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 39 more
Source: ClinicalTrials.gov public record
Updated Dec 12, 2013 · Synced Sep 28, 2026, 10:14 AM EDT
Not yet recruiting Phase 2Phase 3 Interventional

Synergistic Minimally Invasive Surgery and Deferoxamine in ICH

NCT07162363
View directory record Official record
Conditions
Intracerebral Hemorrhage, ICH - Intracerebral Hemorrhage
Interventions
Minimally Invasive surgery (MIS), Deferoxamine, Standard Medical Care (SMD)
Procedure · Drug · Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 80 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated No phase listed Observational

Improving Patient Access to Stroke Therapy Study

NCT01870492
View directory record Official record
Conditions
Ischemic Stroke, Transient Ischemic Attack
Interventions
Activase, Endovascular therapy
Drug · Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 2, 2017 · Synced Sep 28, 2026, 10:14 AM EDT
Not yet recruiting Phase 1 Interventional

Safety Of A Second Dose Of Tenecteplase In Selected Acute Ischemic Stroke Patients Not Responding To The First Dose

NCT06801054
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Tenecteplase (TNK) (0.25 mg/kg, to maximum of 25mg)
Drug
Lead sponsor
Memorial Hermann Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Sep 28, 2026, 10:14 AM EDT
Completed No phase listed Observational

Early Mobilization of Ischemic Stroke Patients Within 24-hours After Intravenous-Tissue Plasminogen Activator (IV-tPA)

NCT01331200
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 26, 2013 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 2 Interventional Results available

Combination Anti-Platelet and Anti-Coagulation Treatment After Lysis of Ischemic Stroke Trial (CATALIST)

NCT00061373
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Aspirin, tinzaparin sodium, eptifibatide
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2011
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 3, 2013 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 2 Interventional Results available

Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke

NCT01869478
View directory record Official record
Conditions
Stroke, Ischemic Stroke
Interventions
Intravenous Thrombolysis, Endovascular Arterial Reperfusion
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 4, 2016 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 4 Interventional Results available

Assess the Penumbra System in the Treatment of Acute Stroke

NCT01429350
View directory record Official record
Conditions
Ischemic Stroke
Interventions
intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Penumbra System
Drug · Device
Lead sponsor
Penumbra Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Denver, Colorado • Gainesville, Florida • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 2 Interventional Results available

Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke (CLEAR-FDR)

NCT01977456
View directory record Official record
Conditions
Stroke, Brain Infarction
Interventions
Eptifibatide
Drug
Lead sponsor
Arthur Pancioli
Other
Eligibility
18 Years to 85 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
8
States / cities
Edgewood, Kentucky • Florence, Kentucky • Fort Thomas, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2016 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke

NCT00630396
View directory record Official record
Conditions
Stroke, Acute
Interventions
Minocycline
Drug
Lead sponsor
David Hess, MD
Other
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Lexington, Kentucky • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

The Intravascular Cooling in the Treatment of Stroke 2/3 Trial

NCT01123161
View directory record Official record
Conditions
Stroke, Acute
Interventions
hypothermia and anti-shivering treatment, Group1: IV t-PA and normothermia
Device · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
22 Years to 82 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Newport Beach, California + 25 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Sep 28, 2026, 10:14 AM EDT
Recruiting Not applicable Interventional

Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe

NCT05983757
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Experimental: endovascular thrombectomy in patients who suffer a distal medium vessel occlusion, Standard medical management
Device · Other
Lead sponsor
Raul Nogueira
Other
Eligibility
18 Years and older
Enrollment
584 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
4
States / cities
Atlanta, Georgia • Iowa City, Iowa • Toledo, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 2 Interventional Results available

Safety of Intravenous Thrombolytics in Stroke on Awakening

NCT01643902
View directory record Official record
Conditions
Stroke
Interventions
tPA
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Sep 28, 2026, 10:14 AM EDT
Terminated Phase 1 Interventional

Safety and Efficacy of Tissue Plasminogen Activator (tPA) in Neonates and Infants

NCT00265005
View directory record Official record
Conditions
Thrombosis
Interventions
alteplase
Drug
Lead sponsor
University of Louisville
Other
Eligibility
28 Weeks to 66 Weeks
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Sep 28, 2026, 10:14 AM EDT
Not listed Phase 1Phase 2 Interventional

Platelet Function in Patients With Ischemic Stroke Treated With Anti-thrombotic or Thrombolytic

NCT05415150
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
Thrombolytic Agent
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 9, 2022 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 2 Interventional Results available

Safety of Intravenous Thrombolysis for Wake-up Stroke

NCT01183533
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Alteplase (iv t-PA)
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Birmingham, Alabama • Englewood, Colorado • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Sep 28, 2026, 10:14 AM EDT
Completed Phase 2 Interventional Results available

Study of the Combination Therapy of Rt-PA and Eptifibatide to Treat Acute Ischemic Stroke

NCT00894803
View directory record Official record
Conditions
Ischemic Stroke, Stroke, Brain Infarction
Interventions
Eptifibatide, rt-PA
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 85 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
20
States / cities
Los Angeles, California • San Diego, California • Santa Monica, California + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2014 · Synced Sep 28, 2026, 10:14 AM EDT