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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 2 Interventional Results available

Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors

NCT01217437
View directory record Official record
Conditions
Central Nervous System Neoplasm, Pineoblastoma, Recurrent Medulloblastoma, Recurrent Primitive Neuroectodermal Tumor, Refractory Medulloblastoma, Refractory Peripheral Primitive Neuroectodermal Tumor
Interventions
Bevacizumab, Irinotecan Hydrochloride, Temozolomide
Biological · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
Up to 21 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2021
U.S. locations
136
States / cities
Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 103 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 2Phase 3 Interventional Results available

D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD

NCT00356278
View directory record Official record
Conditions
Stress Disorder, Post Traumatic
Interventions
D-Cycloserine, Alprazolam, Virtual Reality Exposure Therapy, Placebo
Drug · Behavioral
Lead sponsor
Emory University
Other
Eligibility
21 Years to 65 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD

NCT00371176
View directory record Official record
Conditions
Combat Disorders, Stress Disorders, Post-Traumatic
Interventions
Exposure therapy, D-Cycloserine, Placebo pill
Behavioral · Drug · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 3, 2014 · Synced Sep 21, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional

The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV

NCT07226128
View directory record Official record
Conditions
HIV, Depression in Adults, Insulin Resistance, Cognitive Behavior Therapy
Interventions
Internet cognitive behavioral therapy (iCBT-D), Active Control (AC)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

NCT00307203
View directory record Official record
Conditions
Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
Interventions
bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 21, 2026, 4:54 PM EDT
Active, not recruiting Not applicable Interventional

Digital CBT for Insomnia and Depression

NCT05456607
View directory record Official record
Conditions
Depression, Insomnia
Interventions
Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Depression, Mood Monitoring
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals

NCT00218062
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
D-Amphetamine 30mg, D-Amphetamine 60mg, Modafinil 200mg, Modafinil 400mg, Therapy, Placebo
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 55 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Sep 21, 2026, 4:54 PM EDT
Active, not recruiting Not applicable Interventional

The Transitions Project: Supporting Adults During the Shift From Cancer Treatment to Surveillance

NCT04450043
View directory record Official record
Conditions
Non Small Cell Lung Cancer, Small-cell Lung Cancer, Mesothelioma, Cognitive Behavioral Therapy
Interventions
Run-In Sessions 1-5, RCT Transitions Program Sessions 1-5, RCT Control Session
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 4 Interventional Results available

D-Cycloserine Enhancement of Exposure in Social Phobia

NCT00633984
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
Cognitive Behavioral Group Therapy (CBGT), D-Cycloserine, Placebo
Behavioral · Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 13, 2014 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Results available

Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth

NCT01157416
View directory record Official record
Conditions
Posttraumatic Stress Disorders, PTSD
Interventions
D-cycloserine, Placebo pill, CBT
Drug · Behavioral
Lead sponsor
Tulane University School of Medicine
Other
Eligibility
7 Years to 12 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Enhancing Digital CBT-I to Improve Adherence and Reduce Disparities

NCT05182372
View directory record Official record
Conditions
Insomnia
Interventions
Enhanced dCBT-I
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Treatment for Depression Among HIV-Infected Youth

NCT01049789
View directory record Official record
Conditions
HIV, Depression, HIV Infections
Interventions
COMB - Combination Cognitive Behavioral Therapy and Medication Management, TAU - Treatment as Usual
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 24 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
4
States / cities
Tampa, Florida • The Bronx, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

Preventing Persistent Post-Surgical Pain and Dysfunction

NCT03965897
View directory record Official record
Conditions
Pain, Function, Anxiety, Depression, Arthroplasty, Replacement, Knee, Veterans
Interventions
Acceptance and Commitment Therapy (ACT), Attention Control (AC)
Behavioral · Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
402 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 3 Interventional Results available

Effect of D-cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia

NCT00515879
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
D-cycloserine, Cognitive behavioral therapy (CBT), Placebo
Drug · Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
169 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2019 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Results available

Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder

NCT00790868
View directory record Official record
Conditions
Panic Disorder
Interventions
d-cycloserine, placebo
Drug
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 80 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
4
States / cities
Hartford, Connecticut • Chicago, Illinois • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2018 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

D-Cycloserine Augmentation to CBT With Exposure and Response Prevention in Adults and Adolescents With OCD

NCT01172873
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
D-cycloserine, Exposure and Response Prevention (EX/RP)
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
12 Years to 17 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2014 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 4 Interventional Results available

Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia

NCT00742079
View directory record Official record
Conditions
Schizophrenia
Interventions
D-cycloserine, Cognitive Behavioral Therapy
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Treatment for Teens With Alcohol Abuse and Depression

NCT02227589
View directory record Official record
Conditions
AOD Use, Abuse, and Dependence, Depression
Interventions
MET/CBT-12, CBT-D, D-TAU
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
13 Years to 263 Months
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Farmington, Connecticut • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 4 Interventional

Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

NCT00021528
View directory record Official record
Conditions
Depression
Interventions
citalopram, BuproprionSR, buspirone, Lithium, mirtazapine, nortriptyline, sertraline, tranylcypromine, VenlafaxineXR, Cognitive Therapy, T3 (Triiodothyronine)
Drug · Behavioral
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 75 Years
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
41
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Chula Vista, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2009 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional Results available

2/2 D-Cycloserine Augmentation of CBT for Pediatric OCD

NCT01404208
View directory record Official record
Conditions
Obsessive-Compulsive Disorder
Interventions
D-Cycloserine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
7 Years to 17 Years
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Youth Partners in Care: Depression and Quality Improvement

NCT02030782
View directory record Official record
Conditions
Depression
Interventions
Quality Improvement (QI) for depression, Usual Care
Other
Lead sponsor
Agency for Healthcare Research and Quality (AHRQ)
Federal
Eligibility
13 Years to 21 Years
Enrollment
418 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
5
States / cities
Los Angeles, California • Venice, California • Ventura, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2014 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder

NCT02066792
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
D-Cycloserine, Placebo, Cognitive Behavioral Therapy
Drug · Behavioral
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years to 70 Years
Enrollment
152 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
3
States / cities
Chicago, Illinois • Boston, Massachusetts • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 21, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Results available

Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

NCT00433381
View directory record Official record
Conditions
Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Neoplasm
Interventions
Bevacizumab, Irinotecan Hydrochloride, Temozolomide
Biological · Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
93
States / cities
Mobile, Alabama • Fairbanks, Alaska • Scottsdale, Arizona + 73 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2018 · Synced Sep 21, 2026, 4:54 PM EDT
Terminated Phase 2 Interventional Results available

Efficacy of D-Cycloserine for Enhancing the Effects of CBT for Substance Use

NCT00430573
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
D-cycloserine, Placebo
Drug
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Sep 21, 2026, 4:54 PM EDT