- Conditions
- Non-valvular Atrial Fibrillation, Stroke, Systemic Embolism
- Interventions
- Experimental: Laminar Left Atrial Appendage Closure System, Active Comparator: WATCHMAN / Amulet
- Device
- Lead sponsor
- Biosense Webster, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 1,500 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2024 – 2032
- U.S. locations
- 36
- States / cities
- Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 27 more
Search Results
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Showing 1–24
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matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Atrial Fibrillation, Ischemic Stroke, Acute
- Interventions
- Left Atrial Appendage Occlusion
- Other
- Lead sponsor
- Kansas City Heart Rhythm Research Foundation
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2025
- U.S. locations
- 1
- States / cities
- Overland Park, Kansas
- Conditions
- Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation
- Interventions
- Left Atrial Appendage Occlusion, Mitral Valve Transcatheter Edge to Edge Repair
- Device
- Lead sponsor
- EchoPixel, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Sacramento, California
- Conditions
- Stroke
- Interventions
- Coherex WaveCrest® Left Atrial Appendage Occlusion System, Watchman® LAA Closure Device
- Device
- Lead sponsor
- Coherex Medical
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 248 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2023
- U.S. locations
- 23
- States / cities
- Birmingham, Alabama • Chandler, Arizona • Los Angeles, California + 18 more
- Conditions
- Cardioembolic Stroke, Atrial Fibrillation
- Interventions
- Left atrial appendage closure, SentreHeart Lariat®
- Procedure · Device
- Lead sponsor
- Baylor Research Institute
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 9 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 1
- States / cities
- Plano, Texas
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Closure
- Interventions
- Not listed
- Lead sponsor
- Virginia Commonwealth University
- Other
- Eligibility
- 21 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 1
- States / cities
- Richmond, Virginia
- Conditions
- Atrial Fibrillation
- Interventions
- WATCHMAN LAA Closure Technology
- Device
- Lead sponsor
- Boston Scientific Corporation
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 576 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2019
- U.S. locations
- 3
- States / cities
- Phoenix, Arizona • Lexington, Kentucky • New York, New York
- Conditions
- Stroke
- Interventions
- Amulet Left Atrial Appendage Occluder, WATCHMAN Left Atrial Appendage Closure
- Device
- Lead sponsor
- Abbott Medical Devices
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 1,878 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2024
- U.S. locations
- 85
- States / cities
- Huntsville, Alabama • Phoenix, Arizona • Jonesboro, Arkansas + 70 more
- Conditions
- Left Atrial Appendage Occlusion
- Interventions
- Medtronic LAA Occlusion Device
- Device
- Lead sponsor
- Medtronic Cardiovascular
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 40 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2010
- U.S. locations
- 5
- States / cities
- Rancho Mirage, California • New Haven, Connecticut • Chicago, Illinois + 2 more
- Conditions
- Atrial Fibrillation
- Interventions
- Aegis Sierra Ligation System
- Device
- Lead sponsor
- Aegis Medical Innovations
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 7 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2024
- U.S. locations
- 4
- States / cities
- Santa Monica, California • Rochester, Minnesota • New York, New York + 1 more
- Conditions
- Non-valvular Atrial Fibrillation
- Interventions
- left atrial appendage closure
- Device
- Lead sponsor
- Conformal Medical, Inc
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 64 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2028
- U.S. locations
- 11
- States / cities
- Jonesboro, Arkansas • Santa Monica, California • Manchester, New Hampshire + 7 more
- Conditions
- Left Atrail Appendage Closure: Peri-device Leaks
- Interventions
- leak closure with either detachable embolization coils, vascular plugs/CSO, or RFA
- Other
- Lead sponsor
- Kansas City Heart Rhythm Research Foundation
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 160 participants
- Timeline
- 2015 – 2021
- U.S. locations
- 1
- States / cities
- Overland Park, Kansas
- Conditions
- Atrial Fibrillation
- Interventions
- WATCHMAN FLX
- Device
- Lead sponsor
- Boston Scientific Corporation
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 458 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2021
- U.S. locations
- 29
- States / cities
- Birmingham, Alabama • Phoenix, Arizona • Jonesboro, Arkansas + 24 more
- Conditions
- Atrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure Device
- Interventions
- Dabigatran Etexilate Oral Capsule
- Drug
- Lead sponsor
- Vanderbilt University Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2024
- U.S. locations
- 1
- States / cities
- Nashville, Tennessee
- Conditions
- PFA Ablation and LAAC Procedures
- Interventions
- Watchman FLX™ Pro device.
- Device
- Lead sponsor
- Heart Rhythm Clinical and Research Solutions, LLC
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 122 participants
- Timeline
- 2025 – 2026
- U.S. locations
- 15
- States / cities
- Birmingham, Alabama • San Francisco, California • Littleton, Colorado + 12 more
- Conditions
- Atrial Fibrillation
- Interventions
- Left Atrial Appendage Occlusion
- Procedure
- Lead sponsor
- American College of Cardiology
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 3,000 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2029
- U.S. locations
- 1
- States / cities
- Washington D.C., District of Columbia
- Conditions
- Atrial Fibrillation, Stroke
- Interventions
- Imaging guidance with TEE and ICE for Left atrial appendage closure
- Device
- Lead sponsor
- Kansas City Heart Rhythm Research Foundation
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 52 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2025
- U.S. locations
- 1
- States / cities
- Overland Park, Kansas
- Conditions
- Atrial Fibrillation, Stroke
- Interventions
- CLAAS, WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder
- Device
- Lead sponsor
- Conformal Medical, Inc
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 1,600 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2031
- U.S. locations
- 78
- States / cities
- Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 66 more
- Conditions
- Atrial Fibrillation, Atrial Arrhythmia
- Interventions
- Data collection
- Other
- Lead sponsor
- University of Chicago
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 198 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2026
- U.S. locations
- 10
- States / cities
- Chicago, Illinois • Evanston, Illinois • Boston, Massachusetts + 4 more
- Conditions
- Atrial Fibrillation, Stroke, Bleeding
- Interventions
- Left atrial appendage occlusion (LAAO)
- Device
- Lead sponsor
- Abbott Medical Devices
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 610 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2027
- U.S. locations
- 16
- States / cities
- Phoenix, Arizona • Little Rock, Arkansas • Jacksonville, Florida + 13 more
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Closure, Cardiovascular Diseases
- Interventions
- No investigational intervention administered
- Other
- Lead sponsor
- Anumana, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025
- U.S. locations
- 6
- States / cities
- Jonesboro, Arkansas • Boston, Massachusetts • New Bedford, Massachusetts + 3 more
- Conditions
- Atrial Fibrillation, Stroke, Bleeding, Leakage of Cardiac Device
- Interventions
- Peri-device leakage closure after left atrial appendage occlusion
- Device
- Lead sponsor
- Cardiovascular Center Frankfurt
- Other
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 85 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2021
- U.S. locations
- 7
- States / cities
- Phoenix, Arizona • La Jolla, California • Overland Park, Kansas + 4 more
- Conditions
- Atrial Fibrillation, GI Bleeding
- Interventions
- LAAC with Watchman FLX device
- Device
- Lead sponsor
- Kansas City Heart Rhythm Research Foundation
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 73 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2025
- U.S. locations
- 4
- States / cities
- Overland Park, Kansas • Kansas City, Missouri
- Conditions
- Non-valvular Atrial Fibrillation
- Interventions
- Left Atrial Appendage Closure
- Device
- Lead sponsor
- Biosense Webster, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 58 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2022 – 2028
- U.S. locations
- 7
- States / cities
- Tucson, Arizona • Jonesboro, Arkansas • La Jolla, California + 3 more