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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Melatonin Clear all
Completed No phase listed Observational Accepts healthy volunteers

Circadian Regulation of Sleep in Habitual Short Sleepers and Long Sleepers

NCT00001546
View directory record Official record
Conditions
Sleep Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1996 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Phase 1Phase 2 Interventional

The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program

NCT02431728
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Melatonin, Matched Placebo
Dietary Supplement
Lead sponsor
Duquesne University
Other
Eligibility
18 Years and older · Male only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 7, 2016 · Synced Jul 22, 2026, 11:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Examining the Biological Factors That Affect Sleep Duration

NCT00607204
View directory record Official record
Conditions
Sleep, Circadian Rhythm, Cognitive Performance
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 35 Years
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2013 · Synced Jul 22, 2026, 11:09 PM EDT
Withdrawn Not applicable Interventional

Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes

NCT06292000
View directory record Official record
Conditions
PreDiabetes, Obesity, Inactivity/Low Levels of Exercise
Interventions
AM Exercise, PM Exercise
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 40 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Potential Effects of Inofolic Plus on Abnormal Ovarian Reserve Parameters in Subfertile Women

NCT01290432
View directory record Official record
Conditions
Infertility, Female
Interventions
Inofolic Plus
Dietary Supplement
Lead sponsor
Palm Beach Center for Reproductive Medicine
Other
Eligibility
18 Years to 42 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Wellington, Florida
Source: ClinicalTrials.gov public record
Updated May 24, 2012 · Synced Jul 22, 2026, 11:09 PM EDT
Active, not recruiting Early Phase 1 Interventional

Melatonin and Osteogenic Loading on Osteopenia

NCT04233112
View directory record Official record
Conditions
Osteopenia
Interventions
Melatonin 5 mg, Osteogenic loading, Mock for Osteogenic Loading, Placebo (plant fiber) for melatonin
Drug · Device
Lead sponsor
Duquesne University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional

Out-patient Wake Therapy, Light Therapy and Sleep Phase Advance for Depression

NCT02750631
View directory record Official record
Conditions
Unipolar Depression
Interventions
Triple Therapy
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2017 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity

NCT06146712
View directory record Official record
Conditions
Sleep
Interventions
Asutra's 'Dream the night away' nighttime lotion
Other
Lead sponsor
Asutra
Industry
Eligibility
18 Years to 59 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Nov 26, 2023 · Synced Jul 22, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia

NCT06694441
View directory record Official record
Conditions
Insomnia
Interventions
Light Exposure, Placebo
Other
Lead sponsor
Northwestern University
Other
Eligibility
55 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Phase 1 Interventional Results available

Melatonin Use After Primary Total Joint Arthroplasty

NCT04795336
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Melatonin 5 mg, Placebo
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 95 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Phase 2 Interventional

Melatonin and Radiation Therapy in Treating Patients With Brain Metastases

NCT00031967
View directory record Official record
Conditions
Metastatic Cancer, Radiation Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
therapeutic melatonin, radiation therapy
Drug · Radiation
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
0 Years to 120 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
215
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 166 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Phase 1Phase 2 Interventional

Melatonin and Sleep in Preventing Delirium in the Hospital

NCT02597231
View directory record Official record
Conditions
Delirium
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Scripps Health
Other
Eligibility
65 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleep/Wake Cycle and Depression: An Imaging and Treatment Study

NCT04350567
View directory record Official record
Conditions
Depression; Major Depressive Disorder
Interventions
Sleep Deprivation
Other
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 100 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1

NCT02642640
View directory record Official record
Conditions
Glucose, Circadian Rhythm, Melatonin, Genes
Interventions
melatonin, placebo
Dietary Supplement · Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 22, 2026, 11:09 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.

NCT02631148
View directory record Official record
Conditions
Obesity, Prediabetic State
Interventions
Melatonin, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Melatonin Treatment for Induced Transient Insomnia

NCT00950885
View directory record Official record
Conditions
Delayed Sleep Phase Disorder, Jet-lag, Shift-work Disorder
Interventions
Low Dose Melatonin, Placebo, High Dose Melatonin
Biological
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2017 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.

NCT03368352
View directory record Official record
Conditions
Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress, Neurocognitive Dysfunction
Interventions
Melatonin, Hypoxia
Dietary Supplement · Other
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 30, 2019 · Synced Jul 22, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

Sleep and Circadian Mechanisms in Hypertension

NCT05184933
View directory record Official record
Conditions
Hypertension, Cardiovascular Diseases, Cardiovascular Risk Factors, Circadian Rhythms, Sleep
Interventions
At-home Polysomnography, Circadian Protocol, Rested Wakefulness Trial, Overnight Sleep Trial, Regularized Sleep Schedule
Other · Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
25 Years to 64 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jul 22, 2026, 11:09 PM EDT
Terminated Phase 2 Interventional Results available

Pilot Study of Sleep Therapy and Biomarkers in Children With Autism Spectrum Disorders

NCT02487082
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Melatonin and Donepezil, Placebo
Drug · Other
Lead sponsor
Stony Brook University
Other
Eligibility
4 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2024 · Synced Jul 22, 2026, 11:09 PM EDT
Terminated Phase 1Phase 2 Interventional

Melatonin Effects on Luteinizing Hormone

NCT00288262
View directory record Official record
Conditions
Hot Flashes
Interventions
melatonin 0.5 mg
Drug
Lead sponsor
Scripps Health
Other
Eligibility
50 Years to 70 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2006 · Synced Jul 22, 2026, 11:09 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19

NCT05045937
View directory record Official record
Conditions
Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis
Interventions
Ivermectin
Drug
Lead sponsor
Patrick Robinson
Other
Eligibility
12 Years to 110 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Antonio, Florida
Source: ClinicalTrials.gov public record
Updated Apr 26, 2022 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction

NCT04868539
View directory record Official record
Conditions
Glucose Intolerance, Sleep Deprivation, Sleep
Interventions
Sleep Restriction with ALAN first, then Sleep Restriction without ALAN, Sleep Restriction without ALAN first, then sleep restriction with ALAN
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
20 Years to 40 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 22, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

NCT07049783
View directory record Official record
Conditions
Young Adults, Hypertension, Post-Exercise Hypotension, Circadian Rhythm
Interventions
Exercise
Behavioral
Lead sponsor
Freda Patterson
Other
Eligibility
18 Years to 39 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Aug 16, 2025 · Synced Jul 22, 2026, 11:09 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder

NCT01428661
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
tasimelteon, placebo
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
507 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
40
States / cities
Garden Grove, California • Irvine, California • Los Alamitos, California + 36 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2015 · Synced Jul 22, 2026, 11:09 PM EDT