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Showing 1–24 of 36 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Pacemaker Rate Clear all
Active, not recruiting Not applicable Interventional

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

NCT05839730
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy
Interventions
Pacemaker PLR + TRT ON, Pacemaker non-pacing mode or an exertional rate-adaptive pacing mode with no planned pacing at rest.
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
8
States / cities
Naples, Florida • O'Fallon, Illinois • Springfield, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Not applicable Interventional Results available

APPROPRIATE - Rate Adaptive Pacing Sensor

NCT00757666
View directory record Official record
Conditions
Heart Diseases
Interventions
Rate adaptive pacemaker
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
566 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Jonesboro, Arkansas • Davenport, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 13, 2017 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated No phase listed Observational

Cardiac Output in Heart Failure Patients With Mechanical Pumps

NCT05195931
View directory record Official record
Conditions
Heart Failure, Systolic, Mechanical Circulatory Support, Cardiovascular Hemodynamics
Interventions
preload challenge, afterload challenge, contractility assessment
Diagnostic Test
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 80 Years
Enrollment
7 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Sep 8, 2026, 5:00 PM EDT
Recruiting Not applicable Interventional

ELEVATE-HFpEF Clinical Study

NCT06678841
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction (HFpEF)
Interventions
Personalized cardiac pacing
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
40 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
26
States / cities
Phoenix, Arizona • San Francisco, California • Hartford, Connecticut + 22 more
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Not applicable Interventional Results available

Reducing Episodes by Septal Pacing Efficacy Confirmation Trial (RESPECT)

NCT00289289
View directory record Official record
Conditions
Atrial Fibrillation, Tachycardia, Supraventricular, Arrhythmia, Bradycardia
Interventions
Intervention Pacing Features
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
Not listed
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
34
States / cities
Little Rock, Arkansas • Rancho Mirage, California • San Diego, California + 31 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2012 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Not applicable Interventional Results available

Biventricular Pacing After Cardiopulmonary Bypass

NCT00498940
View directory record Official record
Conditions
Heart Failure
Interventions
Optimization Testing, Temporary Biventricular Pacing
Device
Lead sponsor
Henry M. Spotnitz
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Ivabradine for Rate Control in Permanent Atrial Fibrillation

NCT03987204
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Fibrillation, Persistent
Interventions
Ivabradine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Phase 4 Interventional

MAKE IT CLEAN, Impact of Pocket Revision on the Rate of Infection and Other Complications in Patients Requiring Pocket Manipulation for Generator Replacement and/or Lead Replacement or Revision: A Prospective Randomized Study

NCT00599261
View directory record Official record
Conditions
Infection
Interventions
ICD/pacemaker pocket revision
Procedure
Lead sponsor
Dhanunjaya Lakkireddy, MD, FACC
Other
Eligibility
18 Years and older
Enrollment
265 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2013 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Specialized Pacing for Patients With Congenital Heart Disease

NCT03361189
View directory record Official record
Conditions
Congenital Heart Disease, Bradycardia Sinus
Interventions
Closed loop stimulation, Standard rate response
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
14 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Sep 8, 2026, 5:00 PM EDT
Completed No phase listed Observational

A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction

NCT02027909
View directory record Official record
Conditions
Sinus Node Dysfunction
Interventions
Reprogramming dual chamber pacemaker
Device
Lead sponsor
Arun Rao
Other
Eligibility
60 Years to 95 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Kingsport, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 24, 2018 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Not applicable Interventional Results available

Restoration of Chronotropic Competence in Heart Failure Patients With Normal Ejection Fraction

NCT00670111
View directory record Official record
Conditions
Heart Failure
Interventions
Insignia Plus / Ultra (Guidant/Boston Scientific)
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
5
States / cities
Jonesboro, Arkansas • Louisville, Kentucky • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Sep 8, 2026, 5:00 PM EDT
Completed No phase listed Observational Results available

REPLACE: Implantable Cardiac Pulse Generator Replacement Registry

NCT00395447
View directory record Official record
Conditions
Device Replacement, Elective Replacement (ERI), Device Advisory, Device Upgrade, Postoperative Complications
Interventions
Straight-forward Device Replacement, Device Replacement with Upgrade
Procedure
Lead sponsor
Biotronik, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,744 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
71
States / cities
Birmingham, Alabama • Mesa, Arizona • Modesto, California + 58 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2015 · Synced Sep 8, 2026, 5:00 PM EDT
Recruiting Not applicable Interventional

Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)

NCT03588286
View directory record Official record
Conditions
Sudden Cardiac Death
Interventions
Electrophysiology study (EPS), Standard Care, Cardiac Magnetic Resonance (CMR)
Procedure · Other
Lead sponsor
Western Sydney Local Health District
Other
Eligibility
18 Years to 85 Years
Enrollment
1,058 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Not applicable Interventional

PITA-HF: Feasibility, Safety, and Tolerability

NCT04159454
View directory record Official record
Conditions
Heart Failure, Dilated Cardiomyopathy
Interventions
PITA
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 13, 2023 · Synced Sep 8, 2026, 5:00 PM EDT
Completed No phase listed Observational

The Atrial High Rate Episodes in Pacemaker Patients

NCT00627328
View directory record Official record
Conditions
Arrhythmia, Atrial Fibrillation, Atrioventricular Block, Bradycardia, Sick Sinus Syndrome
Interventions
Not listed
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
50 Years and older
Enrollment
427 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2004
U.S. locations
37
States / cities
Hot Springs, Arkansas • Little Rock, Arkansas • Fresno, California + 34 more
Source: ClinicalTrials.gov public record
Updated Mar 2, 2008 · Synced Sep 8, 2026, 5:00 PM EDT
Completed No phase listed Observational

The MagnaSafe Registry: Determining the Risks of Magnetic Resonance Imaging (MRI) in the Presence of Pacemakers and Implantable Cardioverter Defibrillators (ICDs)

NCT00907361
View directory record Official record
Conditions
Need for MRI Imaging With Pacemaker or, Implantable Cardioverter Defibrillator Implanted
Interventions
MRI with pacemaker or ICD
Device
Lead sponsor
Scripps Health
Other
Eligibility
18 Years and older
Enrollment
2,039 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
21
States / cities
Burbank, California • La Jolla, California • Los Angeles, California + 16 more
Source: ClinicalTrials.gov public record
Updated Nov 22, 2015 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Phase 3 Interventional Results available

AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study

NCT00589303
View directory record Official record
Conditions
Atrial Fibrillation, Heart Failure
Interventions
FDA approved rate and rhythm control drugs, AV Node ablation and device implant
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
65 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
5
States / cities
Scottsdale, Arizona • Evansville, Indiana • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2013 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Blended Sensor Efficiency on Relieving the Heart's Inability to Increase Its Rate During Exercise

NCT01619800
View directory record Official record
Conditions
Chronotropic Incompetence
Interventions
Blended Sensor Optimization (BSO), Accelerometer Alone (AA)
Device
Lead sponsor
Vivek Reddy
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 17, 2017 · Synced Sep 8, 2026, 5:00 PM EDT
Completed No phase listed Observational

Necklace-Shaped Sensor for Non-Invasive Remote Monitoring of Vitals

NCT02337790
View directory record Official record
Conditions
Heart Failure, Hypertension
Interventions
Not listed
Lead sponsor
Baxter Healthcare Corporation
Industry
Eligibility
18 Years to 90 Years
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Imperial, California
Source: ClinicalTrials.gov public record
Updated Dec 29, 2015 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Not applicable Interventional

Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)

NCT06601322
View directory record Official record
Conditions
Left Branch Bundle Block, RV - Right Ventricular Abnormality
Interventions
Pacemaker Interrogation and Electrocardiogram (ECG):, Cardiopulmonary Exercise Test (CPET) and Exercise Stress Cardiac Magnetic Resonance (ExeCMR, Continuous pacemaker telemetry (CPT)
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 8, 2026, 5:00 PM EDT
Terminated Not applicable Interventional Results available

MIRACLE EF Clinical Study

NCT01735916
View directory record Official record
Conditions
Congestive Heart Failure, Left Bundle Branch Block, Systolic Heart Failure
Interventions
CRT-P Implant, CRT-P OFF
Device
Lead sponsor
Medtronic Cardiac Rhythm and Heart Failure
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
69
States / cities
Concord, California • La Jolla, California • Los Angeles, California + 62 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 8, 2026, 5:00 PM EDT
Recruiting Not applicable Interventional

Elevated Rate Pacing of Cardiac Amyloidosis

NCT07583823
View directory record Official record
Conditions
Cardiac Amyloidosis, Pacemaker
Interventions
Pacemaker Rate
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Phase 4 Interventional Results available

Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response

NCT00355797
View directory record Official record
Conditions
Bradycardia
Interventions
Closed Loop Stimulation (CLS), Standard Rate Adaptive (R) Technology, Non-rate adaptive (DDD) pacing
Device
Lead sponsor
Biotronik, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,491 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
99
States / cities
Albertville, Alabama • Gadsden, Alabama • Jasper, Alabama + 82 more
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Sep 8, 2026, 5:00 PM EDT
Completed Phase 4 Interventional

Syncope: Pacing or Recording in the Later Years

NCT01423994
View directory record Official record
Conditions
Syncope, Heart Block, Conduction Disorder of the Heart
Interventions
pacemaker, implantable loop recorder
Procedure
Lead sponsor
Canadian Institutes of Health Research (CIHR)
Government
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Sep 8, 2026, 5:00 PM EDT