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ClinicalTrials.gov public records Last synced Oct 8, 2026, 4:37 PM EDT

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Showing 49–72 of 92 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: transcatheter aortic valve replacement (TAVR) Clear all
Completed Phase 4 Interventional Results available

Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR)

NCT02486367
View directory record Official record
Conditions
Aortic Stenosis, Inflammation, Thrombosis
Interventions
Clopidogrel, Ticagrelor
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Oct 8, 2026, 4:37 PM EDT
Not listed No phase listed Observational

MyLeukoMAP™ Genomic Survival Prediction Assay Pivotal Clinical Study

NCT05258942
View directory record Official record
Conditions
Heart Failure
Interventions
Observational
Other
Lead sponsor
LeukoLifeDx Inc
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Timeline
2022 – 2023
U.S. locations
3
States / cities
New Haven, Connecticut • Orlando, Florida • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Oct 8, 2026, 4:37 PM EDT
Completed Phase 3 Interventional Results available

Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)

NCT02833948
View directory record Official record
Conditions
Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Ventricular Outflow Obstruction, Thrombosis
Interventions
Acetylsalicylic acid, Clopidogrel, Rivaroxaban
Drug
Lead sponsor
ECRI bv
Industry
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Los Angeles, California • New York, New York • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 8, 2026, 4:37 PM EDT
Completed No phase listed Observational Results available

TEE 3D RV Assessment for SAVR, Mini AVR, and TAVR

NCT05804240
View directory record Official record
Conditions
Right Ventricular Dysfunction
Interventions
3D TEE RVEF
Diagnostic Test
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 8, 2026, 4:37 PM EDT
Active, not recruiting Not applicable Interventional

EARLY TAVR: Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis

NCT03042104
View directory record Official record
Conditions
Heart Diseases, Aortic Stenosis, Severe
Interventions
Edwards SAPIEN 3 / SAPIEN 3 Ultra THV
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
65 Years and older
Enrollment
901 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2032
U.S. locations
74
States / cities
Phoenix, Arizona • Burlingame, California • Los Angeles, California + 62 more
Source: ClinicalTrials.gov public record
Updated May 13, 2024 · Synced Oct 8, 2026, 4:37 PM EDT
Recruiting No phase listed Observational

Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR

NCT07309029
View directory record Official record
Conditions
Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation
Interventions
Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
Device
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Detroit, Michigan • Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Oct 8, 2026, 4:37 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Artificial Intelligence (AI) Enabled, Cloud-based ECG Diagnostic Solution (ZBPro) Feasibility Testing

NCT06013917
View directory record Official record
Conditions
Arrhythmias, Cardiac
Interventions
Cardiac Monitoring
Device
Lead sponsor
ZBeats INC
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2023 · Synced Oct 8, 2026, 4:37 PM EDT
Completed Not applicable Interventional Results available

WATCH-TAVR, WATCHMAN for Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement

NCT03173534
View directory record Official record
Conditions
Atrial Fibrillation, Aortic Valve Stenosis
Interventions
WATCHMAN, TAVR
Device
Lead sponsor
samir kapadia
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
32
States / cities
Phoenix, Arizona • Burlingame, California • Santa Barbara, California + 27 more
Source: ClinicalTrials.gov public record
Updated May 22, 2024 · Synced Oct 8, 2026, 4:37 PM EDT
Not listed Phase 2 Interventional

TranScatheter Aortic Valve RepLacement System US Feasibility Trial

NCT01932099
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Transcatheter aortic valve replacement
Device
Lead sponsor
Direct Flow Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
6
States / cities
Sacramento, California • Chicago, Illinois • Detroit, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Oct 8, 2026, 4:37 PM EDT
Completed Not applicable Interventional Results available

The Medtronic TAVR 2.0 US Clinical Study

NCT02738853
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Medtronic Transcatheter Aortic Valve 2.0 Replacement System
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
Not listed
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
8
States / cities
New Haven, Connecticut • Kansas City, Kansas • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Oct 8, 2026, 4:37 PM EDT
Completed No phase listed Observational

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)

NCT04827238
View directory record Official record
Conditions
Aortic Stenosis, Aortic Valve Stenosis
Interventions
Standardized Invasive Hemodynamics
Diagnostic Test
Lead sponsor
University of British Columbia
Other
Eligibility
Not listed
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
Tucson, Arizona • Boca Raton, Florida • Indianapolis, Indiana + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2025 · Synced Oct 8, 2026, 4:37 PM EDT
Not listed Not applicable Interventional

Transcatheter Aortic Valve Replacement System Pivotal Trial

NCT02163850
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Direct Flow Medical, Commercially Available
Device
Lead sponsor
Direct Flow Medical, Inc.
Industry
Eligibility
Not listed
Enrollment
878 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
3
States / cities
New York, New York • Columbus, Ohio • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2016 · Synced Oct 8, 2026, 4:37 PM EDT
Completed No phase listed Observational

Post-Market Surveillance Registry to Monitor Performance and Safety of V8 Device

NCT02099942
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
V8 Balloon Aortic Valvuloplasty (BAV) Catheter
Device
Lead sponsor
InterValve, Inc.
Industry
Eligibility
Not listed
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
7
States / cities
Los Angeles, California • Minneapolis, Minnesota • Nashville, Tennessee + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2016 · Synced Oct 8, 2026, 4:37 PM EDT
Completed No phase listed Observational

Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement (DEFINE-TAVR) Study.

NCT05567809
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
28 participants
Timeline
2022 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 8, 2026, 4:37 PM EDT
Completed Not applicable Interventional

A pragmatiC sTrategy to Promote actIVity and Enhance Quality of Life AFTER Transcatheter Aortic Valve Replacement

NCT03270124
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Daily Activity Goal, Resistance Exercises, Daily Activity Recording
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
Boston, Massachusetts • Lebanon, New Hampshire • Morristown, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 8, 2026, 4:37 PM EDT
Recruiting Phase 4 Interventional

Patient Quality of Recovery After TAVR With Different Sedation Regimens

NCT07556523
View directory record Official record
Conditions
Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis
Interventions
Propofol, Dexmedetomidine, Midazolam, Fentanyl
Drug
Lead sponsor
David Lyubashevsky
Other
Eligibility
18 Years to 90 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Glenview, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 8, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

NCT04889872
View directory record Official record
Conditions
Aortic Stenosis, Calcific, Aortic Valve Stenosis
Interventions
SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
65 Years and older
Enrollment
2,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2037
U.S. locations
65
States / cities
Huntsville, Alabama • Tucson, Arizona • Los Angeles, California + 52 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 8, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional

Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial

NCT06817148
View directory record Official record
Conditions
Aortic Valve Stenosis, Bicuspid Aortic Valve
Interventions
transcatheter aortic valve replacement (TAVR), surgical aortic valve replacement (SAVR)
Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2037
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Oct 8, 2026, 4:37 PM EDT
Completed Not applicable Interventional Results available

Medtronic CoreValve Evolut R U.S. Clinical Study

NCT02207569
View directory record Official record
Conditions
Aortic Stenosis
Interventions
CoreValve Evolut R TAVR system
Device
Lead sponsor
Medtronic Cardiovascular
Industry
Eligibility
Not listed
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
23
States / cities
Phoenix, Arizona • Los Angeles, California • New Haven, Connecticut + 18 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Oct 8, 2026, 4:37 PM EDT
Recruiting Not applicable Interventional

MRI in Transcatheter Aortic Valve Replacement Patients

NCT05603026
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
Self-expanding valve (Medtronic Evolut FX), Balloon-expanding valve (Edwards Sapien 3 Ultra RESILIA)
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 105 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 8, 2026, 4:37 PM EDT
Not listed Not applicable Interventional

Coronary Access After Supra-Annular THV Implantation

NCT05075590
View directory record Official record
Conditions
Coronary Angiography, Transcatheter Aortic Valve Replacement
Interventions
Coronary Angiography
Diagnostic Test
Lead sponsor
University of British Columbia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Harrisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 8, 2026, 4:37 PM EDT
Terminated Not applicable Interventional Results available

REPRISE IV: LOTUS Edge Valve System in Intermediate Surgical Risk Subjects

NCT03618095
View directory record Official record
Conditions
Aortic Valve Stenosis
Interventions
LOTUS Edge Valve System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
382 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
49
States / cities
Huntsville, Alabama • Tucson, Arizona • Little Rock, Arkansas + 39 more
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Oct 8, 2026, 4:37 PM EDT
Completed Not applicable Interventional Results available

Cerebral Protection in Transcatheter Aortic Valve Replacement

NCT02214277
View directory record Official record
Conditions
Severe Symptomatic Calcified Native Aortic Valve Stenosis
Interventions
Cerebral Protection System-The SENTINEL System with TAVR, TAVR
Device
Lead sponsor
Claret Medical
Industry
Eligibility
18 Years and older
Enrollment
363 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
14
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Clearwater, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated May 11, 2018 · Synced Oct 8, 2026, 4:37 PM EDT
Active, not recruiting Not applicable Interventional

The JenaValve ALIGN-AR Pivotal Trial

NCT04415047
View directory record Official record
Conditions
Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency, Aortic Valve Disease
Interventions
JenaValve Trilogy Heart Valve System
Device
Lead sponsor
JenaValve Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
30
States / cities
Tucson, Arizona • Los Angeles, California • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 8, 2026, 4:37 PM EDT