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Showing 1–24 of 1,108 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Disorder of Knee Clear all
Completed No phase listed Observational

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up

NCT00478894
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
14 Years to 55 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 5, 2026, 8:55 PM EDT
Terminated Phase 4 Interventional Results available

Knee Injection RCT

NCT03694821
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ketorolac Tromethamine Injection, Methylprednisolone Acetate Injection, Hylan G-F 20
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2020 · Synced Sep 5, 2026, 8:55 PM EDT
Recruiting Not applicable Interventional

ARVIS TKA vs Conventional TKA

NCT06663384
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation of Augmented Reality technology in TKA compared to standard TKA
Other
Lead sponsor
Foundation for Orthopaedic Research and Education
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 8, 2024 · Synced Sep 5, 2026, 8:55 PM EDT
Withdrawn Phase 4 Interventional

An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2mL Injection) in the Treatment of Osteoarthritis of the Knee

NCT04201743
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Acellular amniotic membrane derived allograft injection (NuDYN)
Drug
Lead sponsor
Illinois Center for Orthopaedic Research and Education
Other
Eligibility
21 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Westmont, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 4, 2020 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 3 Interventional Results available

A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain

NCT03660943
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Placebo, CNTX-4975-05
Drug
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
40 Years to 95 Years
Enrollment
332 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
30
States / cities
Glendale, Arizona • Phoenix, Arizona • Carmichael, California + 23 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 5, 2026, 8:55 PM EDT
Not listed Phase 3 Interventional

A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions

NCT02746068
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
AXS-02, Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
50 Years and older
Enrollment
346 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
54
States / cities
Birmingham, Alabama • Chandler, Arizona • Phoenix, Arizona + 49 more
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Not applicable Interventional Results available

Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty

NCT05673720
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
active tDCS paired with active MBM, sham tDCS paired with sham MBM
Device
Lead sponsor
Florida State University
Other
Eligibility
50 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 2 Interventional Results available

Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis

NCT05080660
View directory record Official record
Conditions
Osteoarthritis, Osteo Arthritis Knee
Interventions
LY3526318, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
40 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
28
States / cities
Chandler, Arizona • Glendale, Arizona • Tempe, Arizona + 23 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 2 Interventional

Celution Prepared Adipose Derived Regenerative Cells in the Treatment of Osteoarthritis of the Knee

NCT02326961
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Celution Device, Placebo
Device · Other
Lead sponsor
Cytori Therapeutics
Industry
Eligibility
40 Years to 69 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
11
States / cities
Mesa, Arizona • Little Rock, Arkansas • La Mesa, California + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2016 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Not applicable Interventional

The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait

NCT00976079
View directory record Official record
Conditions
Tibial Femoral Knee Osteoarthritis, Osteoarthritis
Interventions
Transcutaneous electrical nerve stimulation (TENS), Placebo TENS
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 13, 2009 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Safety and Efficacy of YM150 in Patients With Knee Replacement Surgery

NCT00595426
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
YM150, Warfarin
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years and older
Enrollment
685 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
44
States / cities
Mobile, Alabama • Phoenix, Arizona • Tuscon, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2013 · Synced Sep 5, 2026, 8:55 PM EDT
Completed No phase listed Observational Results available

Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty

NCT02276040
View directory record Official record
Conditions
Knee Pain Arthritis
Interventions
periarticular bupivicaine and liposomal bupivicaine
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 29, 2017 · Synced Sep 5, 2026, 8:55 PM EDT
Terminated Not applicable Interventional

Virtual Reality for Osteoarthritis Knee Pain Pilot

NCT01899508
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Virtual Reality Training Session, 3D viewer with iPod Touch/iPhone (or similar smartphone)
Procedure · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Sep 5, 2026, 8:55 PM EDT
Not listed No phase listed Observational

Survivorship and Outcomes of Robotically Assisted Patellofemoral UKA

NCT01947686
View directory record Official record
Conditions
Patellofemoral Knee Arthroplasty
Interventions
Robotically guided patellofemoral UKA isolated patellofemoral implants
Device
Lead sponsor
St. Helena Hospital Coon Joint Replacement Institute
Other
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
2
States / cities
St. Helena, California • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 4, 2018 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 2 Interventional

Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis

NCT00303056
View directory record Official record
Conditions
Joint Disease
Interventions
HOE140 Icatibant
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
590 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 16, 2012 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Not applicable Interventional

Engaging African American Older Adults With Arthritis in a Physical Activity Intervention

NCT05652413
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Adapted-Engage-PA
Behavioral
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 5, 2026, 8:55 PM EDT
Not listed Phase 2 Interventional

Intra-articularInjection of Botulinum Toxin Type

NCT00211679
View directory record Official record
Conditions
Arthritis, Pain
Interventions
Botulinum Toxin Type A
Drug
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 20, 2005 · Synced Sep 5, 2026, 8:55 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain

NCT04989660
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Pain Chronic
Interventions
6% aqueous phenol, Isotonic saline
Drug
Lead sponsor
Kessler Foundation
Other
Eligibility
40 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 3 Interventional Results available

Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee

NCT00531427
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis of the Knee
Interventions
Buprenorphine, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
40 Years and older
Enrollment
567 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
87
States / cities
Mobile, Alabama • Chandler, Arizona • Phoenix, Arizona + 73 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2012 · Synced Sep 5, 2026, 8:55 PM EDT
Terminated Phase 4 Interventional

Lidocaine Patch Versus Celecoxib in Pain From Osteoarthritis of the Knee

NCT00904605
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Lidoderm, Celecoxib
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004
U.S. locations
20
States / cities
Hueytown, Alabama • Mesa, Arizona • Oro Valley, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 14, 2010 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Knee Pain Related to Osteoarthritis

NCT05882812
View directory record Official record
Conditions
Osteo Arthritis Knee, Arthritis
Interventions
Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
Device · Drug
Lead sponsor
ZetrOZ, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
3
States / cities
Stamford, Connecticut • Trumbull, Connecticut • Dryden, New York
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 5, 2026, 8:55 PM EDT
Completed Phase 2 Interventional Results available

A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis

NCT02067611
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
X0002, Placebo
Drug
Lead sponsor
Lina Xu
Industry
Eligibility
35 Years to 85 Years
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
20
States / cities
Tempe, Arizona • Carmichael, California • Spring Valley, California + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Sep 5, 2026, 8:55 PM EDT
Terminated Not applicable Interventional

Efficacy and Safety of an Active Pulsed Electromagnetic Field for the Treatment of Osteoarthritis of the Knee

NCT02436590
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Orthofix Physio-Stim Model 3315OA
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Baltimore, Maryland • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Sep 5, 2026, 8:55 PM EDT
Terminated Not applicable Interventional Results available

Evaluating Edema and Range of Motion Using Negative Pressure Therapy vs. Standard Surgical Dressing in Bilateral TKA

NCT04712019
View directory record Official record
Conditions
Surgical Wound, Bilateral Total Knee Arthroplasty, Wounds and Injuries, Joint Diseases, Musculoskeletal Diseases, Edema Leg, Joint Pain, Arthritis Knee
Interventions
Closed Incision Negative Pressure Therapy (ciNPT), Standard Silver-containing Dressing
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
6
States / cities
Annapolis, Maryland • Baltimore, Maryland • Columbia, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Sep 5, 2026, 8:55 PM EDT