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ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:15 AM EDT

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Showing 1–24 of 1,111 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Disorder of Knee Clear all
Completed Not applicable Interventional

Effects of Music Listening on Pain and Patient Satisfaction Within First 48 Hours After Knee Replacment Surgery

NCT02039271
View directory record Official record
Conditions
Adjunctive Music Therapy in Total Knee Replacement
Interventions
Music therapy
Other
Lead sponsor
Loma Linda University
Other
Eligibility
50 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Dec 20, 2016 · Synced Oct 21, 2026, 9:15 AM EDT
Not listed Phase 3 Interventional

Efficacy of Myalgesin™ to Support Joint Function in Patients With Knee Osteoarthritis

NCT00577330
View directory record Official record
Conditions
Osteoarthritis
Interventions
Myalgesin™ (celery seed extract, Boswellia serrata extract, Phellodendron extract)
Dietary Supplement
Lead sponsor
ProThera, Inc.
Industry
Eligibility
50 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Dec 28, 2007 · Synced Oct 21, 2026, 9:15 AM EDT
Active, not recruiting No phase listed Observational

C-STAR Movement Database

NCT05471375
View directory record Official record
Conditions
Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Database Entry
Other
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
Up to 99 Years
Enrollment
250 participants
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 21, 2026, 9:15 AM EDT
Terminated Not applicable Interventional

AcoArt Litos PCB Below-the-knee Global Trial

NCT06330493
View directory record Official record
Conditions
Chronic Limb-Threatening Ischemia
Interventions
PCB, PTA
Device
Lead sponsor
Acotec Scientific Co., Ltd
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
16
States / cities
Concord, California • Fremont, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 21, 2026, 9:15 AM EDT
Not listed Phase 3 Interventional

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

NCT02473198
View directory record Official record
Conditions
Osteoarthritis, Pain
Interventions
Exparel, Femoral Nerve Block Bupivacaine, Toradol, Morphine Sulfate
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
18 Years to 73 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Phase 3 Interventional

Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I

NCT00546507
View directory record Official record
Conditions
Osteoarthritis
Interventions
TDS-943 (topical diclofenac sodium 4% spray), celecoxib, placebo
Drug · Other
Lead sponsor
Mika Pharma GmbH
Industry
Eligibility
40 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
43
States / cities
Huntsville, Alabama • Mobile, Alabama • Mesa, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2010 · Synced Oct 21, 2026, 9:15 AM EDT
Not listed Not applicable Interventional

Use of the LRU Pillow in the Acute Setting Following Total Knee Arthroplasty

NCT01814033
View directory record Official record
Conditions
Osteoarthritis
Interventions
Experimental: LRU Pillow, Control Group
Other
Lead sponsor
Newton-Wellesley Hospital
Other
Eligibility
30 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 9, 2015 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Phase 2 Interventional

ALGRX 4975 After Total Knee Replacement

NCT00132392
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Knee Injuries
Interventions
ALGRX 4975
Drug
Lead sponsor
AlgoRx Pharmaceuticals
Industry
Eligibility
35 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 20, 2006 · Synced Oct 21, 2026, 9:15 AM EDT
Recruiting Not applicable Interventional

Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations

NCT07179016
View directory record Official record
Conditions
Chronic Pain (Back / Neck), Chronic Pain Management, Chronic Knee Pain, Joint Pain
Interventions
Auricular Point Acupressure (APA) - Self Management (SM), Education Control
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 85 Years
Enrollment
693 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Columbia, South Carolina • Fort Worth, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Phase 2, Open Label, Pharmacokinetic (PK) Study of TLC599 in Subjects With Osteoarthritis of the Knee

NCT03754049
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
TLC599, DSP
Drug
Lead sponsor
Taiwan Liposome Company
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
7
States / cities
Phoenix, Arizona • Miami, Florida • Charleston, South Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Oct 21, 2026, 9:15 AM EDT
Withdrawn Not applicable Interventional

Bilateral Versus Unilateral Strength Training After ACLR

NCT06032247
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Atrophy, Muscular, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
Interventions
Resistance exercise program- UL, Resistance exercise program- BL
Behavioral
Lead sponsor
University of Kansas
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 21, 2026, 9:15 AM EDT
Not yet recruiting Not applicable Interventional

A Study of the Effect of a Nurse Navigator Program on High Risk Patients

NCT05592847
View directory record Official record
Conditions
Patient Readmission, Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip, Heart Failure, Pulmonary Disease, Chronic Obstructive, Renal Insufficiency, Body Mass Index, Alcoholism
Interventions
Nurse Navigator Program
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Not applicable Interventional

Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain

NCT02578108
View directory record Official record
Conditions
Osteoarthritis, Knee, Pain, Nerve; Lesion
Interventions
genicular nerve diagnostic block with lidocaine (local anesthetic), genicular nerve radiofrequency ablation
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
30 Years to 80 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 21, 2019 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Not applicable Interventional Results available

Geniculate Artery Embolization for the Treatment of Knee Pain

NCT02850068
View directory record Official record
Conditions
Osteoarthritis Of Knee
Interventions
Geniculate Artery Embolization
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Woodbridge, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Oct 21, 2026, 9:15 AM EDT
Terminated Phase 2 Interventional

A Study Comparing 4 Dose Regimens of PLA-695, Naproxen, and Placebo In Subjects With Osteoarthritis Of The Knee

NCT00396955
View directory record Official record
Conditions
Osteoarthritis
Interventions
PLA-695
Drug
Lead sponsor
Wyeth is now a wholly owned subsidiary of Pfizer
Industry
Eligibility
50 Years to 75 Years
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
39
States / cities
Huntsville, Alabama • Scottsdale, Arizona • Tucson, Arizona + 34 more
Source: ClinicalTrials.gov public record
Updated Dec 28, 2007 · Synced Oct 21, 2026, 9:15 AM EDT
Not listed Phase 1Phase 2 Interventional

APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee

NCT02210468
View directory record Official record
Conditions
Pain, Osteoarthritis
Interventions
APIC-CF, 4 cc, APIC-CF, 2 cc, Placebo Comparator: Saline
Device · Other
Lead sponsor
Cytonics Corporation
Industry
Eligibility
21 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Townsend, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 21, 2015 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Phase 2 Interventional

A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee

NCT02524197
View directory record Official record
Conditions
Osteoarthritis
Interventions
CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg, CR845 5 mg
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
25 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
5
States / cities
Omaha, Nebraska • Las Vegas, Nevada • Greensboro, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Phase 2 Interventional Results available

A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee

NCT01554579
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Gefapixant, Sugar Pill
Drug
Lead sponsor
Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Industry
Eligibility
40 Years to 80 Years
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
34
States / cities
Phoenix, Arizona • San Diego, California • Clearwater, Florida + 29 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2019 · Synced Oct 21, 2026, 9:15 AM EDT
Completed No phase listed Observational

Total Knee Arthroplasty Guidance Systems Study

NCT02830997
View directory record Official record
Conditions
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions
Stereotactic guidance system
Device
Lead sponsor
Ormonde M. Mahoney, MD
Other
Eligibility
45 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Oct 21, 2026, 9:15 AM EDT
Recruiting Not applicable Interventional

SELUTION4BTK Trial

NCT05055297
View directory record Official record
Conditions
Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities
Interventions
SELUTION SLR™ DEB 014, Plain (Uncoated) Balloon Angioplasty (PTA)
Device
Lead sponsor
M.A. Med Alliance S.A.
Industry
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2032
U.S. locations
30
States / cities
Chandler, Arizona • Jonesboro, Arkansas • Little Rock, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers

NCT01943513
View directory record Official record
Conditions
Healthy
Interventions
BIIB023, Placebo
Biological
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 35 Years · Male only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Evansville, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 3, 2014 · Synced Oct 21, 2026, 9:15 AM EDT
Completed Not applicable Interventional

The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait

NCT00976079
View directory record Official record
Conditions
Tibial Femoral Knee Osteoarthritis, Osteoarthritis
Interventions
Transcutaneous electrical nerve stimulation (TENS), Placebo TENS
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2009 · Synced Oct 21, 2026, 9:15 AM EDT
Recruiting No phase listed Observational

FDG PET/MRI Imaging of Patellofemoral Joint Osteoarthritis

NCT07625150
View directory record Official record
Conditions
Patellofemoral Osteoarthritis, Knee Osteoarthritis, Knee Pain, Inflamation
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
50 participants
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Oct 21, 2026, 9:15 AM EDT
Terminated Phase 4 Interventional Results available

Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib.

NCT00484718
View directory record Official record
Conditions
Osteoarthritis
Interventions
celecoxib, Oxycodone, placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
40 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2021 · Synced Oct 21, 2026, 9:15 AM EDT