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ClinicalTrials.gov public records Last synced Oct 29, 2026, 5:45 PM EDT

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Showing 961–984 of 2,566 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Heart Failure Clear all
Completed No phase listed Observational

Prediction of Patient Deterioration Using Machine Learning

NCT05045742
View directory record Official record
Conditions
Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma, Gout Flare, Chronic Kidney Diseases, Hypertensive Urgency, Atrial Fibrillation Rapid, Anticoagulants; Increased
Interventions
Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
526 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 29, 2026, 5:45 PM EDT
Recruiting Not applicable Interventional

A Study Investigating the Impact of IMT With CR On Exercise Responses In HF

NCT07086131
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction
Interventions
Powerbreathe
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 29, 2026, 5:45 PM EDT
Active, not recruiting Not applicable Interventional

Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

NCT03674307
View directory record Official record
Conditions
Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication
Interventions
No screening, Regular Screening
Other
Lead sponsor
University of British Columbia
Other
Eligibility
18 Years and older
Enrollment
3,306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
2
States / cities
Tucson, Arizona • Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 29, 2026, 5:45 PM EDT
Not listed Phase 4 Interventional

Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension

NCT01468571
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
Spironolactone, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 8, 2015 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Medically Used Tailored Traditional Food to Optimize Nutrition in Heart Failure

NCT06549699
View directory record Official record
Conditions
Heart Failure
Interventions
Medically Tailored Meal Program with Traditional Navajo Foods, Usual Care
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
2
States / cities
Gallup, New Mexico • Tohatchi, New Mexico
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Phase 2 Interventional Results available

Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction

NCT02053493
View directory record Official record
Conditions
Heart Failure
Interventions
Isosorbide Mononitrate, Placebo
Drug
Lead sponsor
Adrian Hernandez
Other
Eligibility
50 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
22
States / cities
Newark, Delaware • Atlanta, Georgia • Chicago, Illinois + 12 more
Source: ClinicalTrials.gov public record
Updated Nov 28, 2016 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Phase 3 Interventional

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

NCT00709865
View directory record Official record
Conditions
Renal Insufficiency, Congestive Heart Failure
Interventions
tonapofylline, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
68
States / cities
Huntsville, Alabama • Mobile, Alabama • Fort Smith, Arkansas + 64 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2023 · Synced Oct 29, 2026, 5:45 PM EDT
Terminated Not applicable Interventional Results available

Restoration of Chronotropic Competence in Heart Failure Patients With Normal Ejection Fraction

NCT00670111
View directory record Official record
Conditions
Heart Failure
Interventions
Insignia Plus / Ultra (Guidant/Boston Scientific)
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
5
States / cities
Jonesboro, Arkansas • Louisville, Kentucky • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated May 19, 2017 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI)

NCT04019314
View directory record Official record
Conditions
Heart Failure, Volume Overload, Decompensated Heart Failure, Systolic Heart Failure
Interventions
Blood Collection, Blood Volume Analysis
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Phase 1Phase 2 Interventional

Study to Evaluate the Effects of TRV120027 in Patients With Heart Failure

NCT01187836
View directory record Official record
Conditions
Heart Failure
Interventions
TRV120027, Placebo
Drug
Lead sponsor
Trevena Inc.
Industry
Eligibility
18 Years to 79 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
4
States / cities
Miami, Florida • Baltimore, Maryland • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Implementation Model for Clinical Decision Support for Heart Failure Prescribing

NCT04028557
View directory record Official record
Conditions
Decision Support Systems, Clinical, Heart Failure
Interventions
Decision Support Systems, Clinical
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 6, 2022 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Comparative Effectiveness of 7 Versus 21 Home-delivered Medically Tailored Meals to Improve Malnutrition Risk in Malnourished Patients With Heart Failure

NCT06142903
View directory record Official record
Conditions
Heart Failure, Malnutrition
Interventions
7 versus 21 medically tailored meals per week
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 90 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 20, 2025 · Synced Oct 29, 2026, 5:45 PM EDT
Active, not recruiting Phase 3 Interventional

LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

NCT05983250
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
TNX-103, Placebo
Drug
Lead sponsor
Tenax Therapeutics, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
40
States / cities
Tucson, Arizona • La Jolla, California • Los Angeles, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

"Hub and Satellite" Heart Failure Provider's Network Study

NCT01246050
View directory record Official record
Conditions
Heart Failure
Interventions
HF training, No HF training
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
20 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 30, 2019 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Not applicable Interventional

Optimal Coronary Sinus Lead Implantation Using Intracardiac Impedography and Magnetic Resonance Imaging

NCT01129635
View directory record Official record
Conditions
Heart Failure, Systolic, Left Bundle Branch Block
Interventions
Cardiac Resynchronization Therapy (CRT) implantation
Procedure
Lead sponsor
Emory University
Other
Eligibility
Not listed
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2015 · Synced Oct 29, 2026, 5:45 PM EDT
Terminated Phase 3 Interventional Results available

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

NCT00608140
View directory record Official record
Conditions
Mitral Valve Insufficiency, Heart Failure
Interventions
Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
Procedure · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
8
States / cities
Atlanta, Georgia • Boston, Massachusetts • Minneapolis, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Phase 3 Interventional Results available

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

NCT02924727
View directory record Official record
Conditions
Acute Myocardial Infarction
Interventions
LCZ696 (sacubitril/valsartan), Ramipril, Placebo of LCZ696, Placebo of ramipril, Valsartan, Placebo of valsartan
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
5,669 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
81
States / cities
Birmingham, Alabama • Huntsville, Alabama • Gilbert, Arizona + 74 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 29, 2026, 5:45 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Clinical Utility of Subcutaneous Furosemide in Patients Presenting With Early Signs of Fluid Overload

NCT03359161
View directory record Official record
Conditions
Heart Failure
Interventions
sc2Wear Furosemide Infusor
Combination Product
Lead sponsor
Steward St. Elizabeth's Medical Center of Boston, Inc.
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Brighton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Oct 29, 2026, 5:45 PM EDT
Completed Phase 2 Interventional

A Study of Valsartan Administered Once Daily Versus Twice Daily, in Patients With Stable, Chronic Heart Failure

NCT00294086
View directory record Official record
Conditions
Chronic Heart Failure
Interventions
valsartan 160 mg, valsartan 160 mg BID
Drug
Lead sponsor
Novartis
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Timeline
2005 – 2007
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 8, 2011 · Synced Oct 29, 2026, 5:45 PM EDT
Withdrawn Not applicable Interventional

Body Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular Failure

NCT00811486
View directory record Official record
Conditions
Right Heart Failure, Pulmonary Hypertension
Interventions
Spironolactone and conivaptan
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 28, 2013 · Synced Oct 29, 2026, 5:45 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

NCT04984473
View directory record Official record
Conditions
Healthy, Heart Failure
Interventions
Inspiratory muscle training
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 29, 2026, 5:45 PM EDT
Completed No phase listed Observational

Effectiveness of a Walking Program Modulating Cardioreparative Factors in Heart Failure

NCT00937443
View directory record Official record
Conditions
Heart Failure
Interventions
Physical Fitness, Walking Exercise Group
Other · Biological
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
30 Years to 65 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 29, 2026, 5:45 PM EDT
Not listed Not applicable Interventional

Does Ultrasound Assessment for Extravascular Lung Water and IVC Measurement Affect Outcomes in Inpatient Heart Failure Management?

NCT04436718
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Daily pocus exam
Diagnostic Test
Lead sponsor
Riverside University Health System Medical Center
Other
Eligibility
18 Years to 95 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Moreno Valley, California
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Oct 29, 2026, 5:45 PM EDT
Active, not recruiting Not applicable Interventional

TRISCEND II Pivotal Trial

NCT04482062
View directory record Official record
Conditions
Tricuspid Valve Regurgitation, Tricuspid Valve Insufficiency, Tricuspid Valve Disease, Heart Valve Diseases, Cardiovascular Diseases, Heart Failure
Interventions
Edwards EVOQUE System, Optimal Medical Therapy
Device · Drug
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
864 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
55
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 41 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 29, 2026, 5:45 PM EDT