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ClinicalTrials.gov public records Last synced Oct 9, 2026, 11:57 PM EDT

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Showing 121–144 of 247 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Analgesic Efficacy Clear all
Completed Phase 2 Interventional Results available

Effectiveness of an Opioid Sparing Pain Regimen in Cardiac Surgery

NCT03679013
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Oral Gabapentin and Intravenous Acetaminophen (IV APAP), Opiate based pain regimen.
Drug
Lead sponsor
Inova Health Care Services
Other
Eligibility
18 Years to 85 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Falls Church, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dosimeter Location in Pain Physicians

NCT06309407
View directory record Official record
Conditions
RAD
Interventions
Hand Dosimeters, Standard Practice
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 13, 2024 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 4 Interventional Results available

An Open-label Study of Hydromorphone Oral Solution in Subjects Aged 28 Days to 16 Years for Postoperative Pain

NCT00465647
View directory record Official record
Conditions
Postoperative Pain
Interventions
Hydromorphone
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
28 Days to 16 Years
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
14
States / cities
Little Rock, Arkansas • Orange, California • Stanford, California + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2015 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional Results available

An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA

NCT03661996
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
CNTX-4975-05, Lidocaine without epinephrine, ElastoGel, Breg Ice Water Pump
Drug · Device
Lead sponsor
Centrexion Therapeutics
Industry
Eligibility
40 Years to 95 Years
Enrollment
854 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
28
States / cities
Birmingham, Alabama • Peoria, Arizona • Tucson, Arizona + 24 more
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional Results available

Tanezumab in Osteoarthritis of the Hip or Knee (2)

NCT00863304
View directory record Official record
Conditions
Osteoarthritis
Interventions
tanezumab 10 mg, tanezumab 5 mg, naproxen, placebo
Biological · Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
849 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
95
States / cities
Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 69 more
Source: ClinicalTrials.gov public record
Updated May 17, 2021 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional Results available

Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study

NCT01229449
View directory record Official record
Conditions
Post-operative Pain
Interventions
Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®, Panadeine® Extra, Placebo
Drug
Lead sponsor
Reckitt Benckiser LLC
Industry
Eligibility
16 Years and older
Enrollment
678 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

NCT01427283
View directory record Official record
Conditions
Low Back Pain
Interventions
Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
149
States / cities
Alabaster, Alabama • Birmingham, Alabama • Foley, Alabama + 114 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2015 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 4 Interventional

Anodyne Therapy in Diabetic Sensory Neuropathy

NCT00120341
View directory record Official record
Conditions
Diabetes Mellitus, Diabetic Neuropathy
Interventions
Anodyne Therapy System
Device
Lead sponsor
Scott and White Hospital & Clinic
Other
Eligibility
25 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2007 · Synced Oct 9, 2026, 11:57 PM EDT
Recruiting Phase 4 Interventional

Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

NCT05722002
View directory record Official record
Conditions
Surgery, Pain, Postoperative
Interventions
NSAID, Opioid, Acetaminophen
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
6
States / cities
Ann Arbor, Michigan • Detroit, Michigan • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2026 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional

Extension to Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence

NCT00630201
View directory record Official record
Conditions
Opioid Dependence
Interventions
Probuphine (buprenorphine implant)
Drug
Lead sponsor
Titan Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
15
States / cities
Los Angeles, California • National City, California • Jacksonville, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Dec 31, 2018 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional Results available

Efficacy Study to Evaluate Buprenorphine HCl Buccal Film in Opioid-Experienced Subjects

NCT01675167
View directory record Official record
Conditions
Low Back Pain
Interventions
Buprenorphine, Placebo
Drug
Lead sponsor
BioDelivery Sciences International
Industry
Eligibility
18 Years and older
Enrollment
815 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
66
States / cities
Birmingham, Alabama • Haleyville, Alabama • Mobile, Alabama + 57 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Oct 9, 2026, 11:57 PM EDT
Terminated Phase 2 Interventional Results available

AZD2066 Neuropathic Pain - Mechanical Hypersensitivity

NCT00939094
View directory record Official record
Conditions
Neuropathic Pain, Mechanical Hypersensitivity
Interventions
AZD2066, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 80 Years
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
38
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 35 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Oct 9, 2026, 11:57 PM EDT
Withdrawn Phase 2 Interventional

Efficacy of Acetaminophen in Posterior Fossa Surgery

NCT02532322
View directory record Official record
Conditions
Arnold-Chiari Malformation, Posterior Fossa Tumors
Interventions
IV acetaminophen, normal saline
Drug
Lead sponsor
Children's National Research Institute
Other
Eligibility
2 Years to 12 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Oct 9, 2026, 11:57 PM EDT
Active, not recruiting Phase 4 Interventional

Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain

NCT04296305
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Interventions
Hydromorphone, Placebo Administration, Questionnaire Administration
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 4 Interventional Results available

Genicular Nerve Block for Total Knee Arthroplasty

NCT03706313
View directory record Official record
Conditions
Post-operative Pain
Interventions
15mL 0.25% bupivacaine, Genicular nerve block, Saline
Drug · Procedure
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2021 · Synced Oct 9, 2026, 11:57 PM EDT
Withdrawn Not applicable Interventional

Bupivacaine Injections Into Uterosacral Ligaments During Robotic Assisted Total Hysterectomies

NCT02230735
View directory record Official record
Conditions
Pain
Interventions
Bipivacaine 0.5% with epinephrine, Normal Saline
Drug
Lead sponsor
Souza, Amanda, M.D.
Individual
Eligibility
21 Years to 65 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Farmington Hills, Michigan
Source: ClinicalTrials.gov public record
Updated May 5, 2016 · Synced Oct 9, 2026, 11:57 PM EDT
Terminated Phase 3 Interventional Results available

Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study

NCT01089725
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Pain
Interventions
Placebo IV, Placebo SC, Tanezumab SC, Tanezumab IV
Biological
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 99 Years
Enrollment
385 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
91
States / cities
Montgomery, Alabama • Mesa, Arizona • Phoenix, Arizona + 64 more
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Oct 9, 2026, 11:57 PM EDT
Terminated Phase 2 Interventional

Study to Assess Analgesic Efficacy and Safety of ASP3662 in Subjects With Painful Diabetic Peripheral Neuropathy

NCT02372578
View directory record Official record
Conditions
Painful Diabetic Peripheral Neuropathy (PDPN)
Interventions
ASP3662, pregabalin, ASP3662 placebo, pregabalin placebo
Drug
Lead sponsor
Astellas Pharma Global Development, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
37
States / cities
Anniston, Alabama • Phoenix, Arizona • Fresno, California + 33 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2019 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Efficacy of Transversus Abdominis Plane Block Versus Local Injection of Pain Medication

NCT02314104
View directory record Official record
Conditions
Pain, Postoperative
Interventions
ropivacaine
Drug
Lead sponsor
Liberman, Eric, D.O.
Individual
Eligibility
18 Years and older · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Livingston, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 14, 2015 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional

Safety and Effectiveness of Buprenorphine Transdermal System in Elderly Subjects With Chronic Pain: Pilot Study.

NCT00313833
View directory record Official record
Conditions
Chronic Pain
Interventions
Buprenorphine transdermal delivery system
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2001
U.S. locations
18
States / cities
Birmingham, Alabama • Phoenix, Arizona • Anaheim, California + 15 more
Source: ClinicalTrials.gov public record
Updated May 3, 2006 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate the Analgesic Efficacy of 28 Days' Oral Administration of AZD2066 Compared With Placebo in Patients With Painful Diabetic Neuropathy

NCT00857623
View directory record Official record
Conditions
Pain, Diabetic Neuropathy
Interventions
AZD2066, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 80 Years
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
19
States / cities
Bella Vista, Arkansas • National City, California • Walnut Creek, California + 16 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2012 · Synced Oct 9, 2026, 11:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Epidural Clonidine Versus Corticosteroid for Low Back Pain

NCT02239627
View directory record Official record
Conditions
Back Pain
Interventions
Epidural steroid, Clonidine
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jan 20, 2021 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 4 Interventional Results available

Transverse Abdominis Plane (TAP) Block After Cesarean Delivery

NCT01170702
View directory record Official record
Conditions
Postoperative Pain, Pregnancy, Obesity
Interventions
0.9% Normal Saline, 0.2% Ropivacaine, 0.5% Ropivacaine, 0.75% Ropivacaine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 8, 2021 · Synced Oct 9, 2026, 11:57 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Analgesic Efficacy & Safety of Intravenous (IV) Acetaminophen Versus Placebo for the Treatment of Postop Pain

NCT00564486
View directory record Official record
Conditions
Pain
Interventions
IV Placebo, IV Acetaminophen
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years to 80 Years
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
17
States / cities
Sheffield, Alabama • Phoenix, Arizona • Arcadia, California + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2016 · Synced Oct 9, 2026, 11:57 PM EDT