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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Terminated Not applicable Interventional

Helping Stroke Patients With ThermoSuit Cooling

NCT02453373
View directory record Official record
Conditions
Stroke, Brain Ischemia
Interventions
ThermoSuit Cooling Induction, Magnesium Sulfate, tPA, Propofol, Etomidate, Neurothrombectomy
Device · Drug · Procedure
Lead sponsor
Life Recovery Systems
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
4
States / cities
New Orleans, Louisiana • Danville, Pennsylvania • Wilkes-Barre, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 1 Interventional Results available

The Capillary Index Score Trial

NCT02618031
View directory record Official record
Conditions
Acute Stroke, Brain Ischemia, Ischemic Stroke
Interventions
Endovascular Treatment (EVT)
Procedure
Lead sponsor
Firas Al-Ali
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
6
States / cities
Atlanta, Georgia • New York, New York • Rochester, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Sep 8, 2026, 5:25 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Catheter-directed Thrombolysis Compared to Anticoagulation Alone for Acute Primary Iliofemoral Deep Venous Thrombosis

NCT04411316
View directory record Official record
Conditions
Deep Venous Thrombosis, Post Thrombotic Syndrome
Interventions
Catheter directed thrombolysis plus anticoagulation, Anticoagulation
Combination Product · Drug
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Not applicable Interventional

IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of Major Vessel Occlusion

NCT00624000
View directory record Official record
Conditions
Ischemic Stroke
Interventions
IV tpa (Alteplase) vs IA tpa (Alteplase)
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
19 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2011 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional Results available

Cisplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

NCT00066222
View directory record Official record
Conditions
Lung Cancer
Interventions
Cisplatin, Etoposide, Radiation therapy
Drug · Radiation
Lead sponsor
Radiation Therapy Oncology Group
Network
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2013
U.S. locations
104
States / cities
Birmingham, Alabama • Castro Valley, California • Hayward, California + 74 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2017 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional

A Study to Evaluate the Effects of YM872 on Brain Function and Disability When Administered in Combination With Alteplase (Tissue Plasminogen Activator)

NCT00044057
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
YM872 (zonampanel), t-PA (alteplase)
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2003
U.S. locations
94
States / cities
Mobile, Alabama • Phoenix, Arizona • Tucson, Arizona + 78 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2006 · Synced Sep 8, 2026, 5:25 PM EDT
Active, not recruiting Phase 4 Interventional

Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE

NCT03581877
View directory record Official record
Conditions
Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
Interventions
Alteplase, EKOS
Drug · Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 89 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
2
States / cities
Bay Shore, New York • Queens, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional

Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke

NCT02448069
View directory record Official record
Conditions
Stroke, Cerebral Ischemia
Interventions
Argatroban
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 20, 2017 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacogenetics of Ace Inhibitor-Associated Angioedema

NCT01413542
View directory record Official record
Conditions
Hypertension, Diabetes Type 2
Interventions
Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin, enalaprilat (ACE inhibitor), Glucagon-like peptide 1, brain natriuretic peptide
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Management of Pleural Space Infections

NCT03873766
View directory record Official record
Conditions
Empyema, Pleural, Parapneumonic Effusion
Interventions
Intrapleural Medications, Surgery, Pleural Sampling, Pleural fluid drainage, Protocol Image #1, Surgical Consultation, Protocol Image #2: Chest X-ray PA/Lateral, Quality of Life
Drug · Procedure · Radiation + 2 more
Lead sponsor
Swedish Medical Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 21, 2022 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 3 Interventional

Female Sex is an Independent Predictor of Death and Bleeding Among Fibrinolytic Treated Patients With AMI

NCT00245648
View directory record Official record
Conditions
Myocardial Infarction
Interventions
fibrinolytic therapy or combination reduced fibrinolytic therapy
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 3, 2012 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional Results available

Low-Dose Alteplase to Treat Blood Clots in Deep Leg Veins

NCT00082355
View directory record Official record
Conditions
Acute Deep Venous Thrombosis of the Lower Extremity
Interventions
Alteplase (Activase, Genentech)
Drug
Lead sponsor
Richard Chang, M.D.
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2014
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2014 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 1 Interventional

Low-Dose rtPA to Treat Blood Clots in Major Arm or Neck Veins

NCT00055159
View directory record Official record
Conditions
Thrombosis
Interventions
Pulse-sprayed injection of recombinant tissue plasminogen activator (rtPA)
Procedure
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 1Phase 2 Interventional

In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer

NCT00086723
View directory record Official record
Conditions
Unspecified Adult Solid Tumor, Protocol Specific
Interventions
recombinant tissue plasminogen activator, captopril
Biological · Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 10, 2012 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke

NCT00630396
View directory record Official record
Conditions
Stroke, Acute
Interventions
Minocycline
Drug
Lead sponsor
David Hess, MD
Other
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
2
States / cities
Lexington, Kentucky • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 12, 2012 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional Results available

Safety of Intravenous Thrombolysis for Wake-up Stroke

NCT01183533
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Alteplase (iv t-PA)
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Birmingham, Alabama • Englewood, Colorado • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2014 · Synced Sep 8, 2026, 5:25 PM EDT
Not listed Not applicable Interventional

Healthy Frio: A Rural Community Partnership to Advance Latino Obesity Research

NCT03186885
View directory record Official record
Conditions
Obesity, Nutrition Poor, Physical Activity, Weight Loss
Interventions
Healthy Frio In-Person Family-focused Intervention, Healthy Frio Remote Technology Family-focused Intervention, Control
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
8 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Pearsall, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2022 · Synced Sep 8, 2026, 5:25 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage

NCT01878136
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Cerebral Vasospasm, Cerebral Aneurysm, Hydrocephalus
Interventions
Tissue Plasminogen Activator
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 10, 2015 · Synced Sep 8, 2026, 5:25 PM EDT
Withdrawn Phase 2Phase 3 Interventional

Tenecteplase Versus Alteplase in Ischemic Stroke Management (TALISMAN)

NCT02180204
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Tenecteplase, Alteplase
Drug
Lead sponsor
Reza Behrouz, DO
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 22, 2015 · Synced Sep 8, 2026, 5:25 PM EDT
Recruiting Phase 4 Interventional

Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema

NCT07095361
View directory record Official record
Conditions
Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural, Empyema, Complicated Pleural Effusion/ Empyema, Pleural Effusion Associated With Pulmonary Infection, Pleural Effusion
Interventions
Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily, DNA degradation twice daily
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
6
States / cities
New Haven, Connecticut • Chicago, Illinois • Detroit, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 4 Interventional Results available

Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Pulmonary Embolism

NCT02396758
View directory record Official record
Conditions
Pulmonary Embolism and Thrombosis
Interventions
Ekosonic® Endovascular Device ultrasonic infusion catheter, Recombinant tissue plasminogen activator
Device · Biological
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
16
States / cities
Beverly Hills, California • Tallahassee, Florida • Tampa, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 18, 2021 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional

Intraventricular Rt-PA in Patients With Intraventricular Hemorrhage

NCT00029315
View directory record Official record
Conditions
Cerebral Hemorrhage
Interventions
Recombinant Tissue Plasminogen Activator (rt-PA)
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2015 · Synced Sep 8, 2026, 5:25 PM EDT
Completed No phase listed Observational

Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass

NCT01352143
View directory record Official record
Conditions
Cardiopulmonary Bypass
Interventions
Recombinant activated factor VII, Prothrombin Complex Concentrate
Drug
Lead sponsor
Emory University
Other
Eligibility
Up to 30 Days
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2013 · Synced Sep 8, 2026, 5:25 PM EDT
Completed Phase 2 Interventional Results available

Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation

NCT00224770
View directory record Official record
Conditions
Intracerebral Hemorrhage
Interventions
MIS+Cathflo Activase (drug), Intraoperative stereotactic CT-Guided Endoscopic Surgery
Drug · Procedure
Lead sponsor
Daniel Hanley
Other
Eligibility
18 Years to 80 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
26
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2015 · Synced Sep 8, 2026, 5:25 PM EDT