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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Sponsor: McMaster University Clear all
Active, not recruiting Phase 4 Interventional

Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial

NCT05610319
View directory record Official record
Conditions
Diabetic Macular Edema
Interventions
Faricimab
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
446 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
11
States / cities
Modesto, California • Sacramento, California • Oak Forest, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 1, 2026, 9:55 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Reference Values for Videofluoroscopic Measures of Swallowing

NCT05497219
View directory record Official record
Conditions
Dysphagia, Oropharyngeal
Interventions
Videofluoroscopic Swallowing Study (VF)
Diagnostic Test
Lead sponsor
University Health Network, Toronto
Other
Eligibility
18 Years and older
Enrollment
580 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
3
States / cities
Gainesville, Florida • Cincinnati, Ohio • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Not applicable Interventional

Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome

NCT04437537
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Bioresorbable 3D electrospun synthetic matrix
Device
Lead sponsor
RenovoDerm
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Northampton, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 1, 2026, 9:55 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Patient Satisfaction With Facial Appearance: Development and Validation of a New Patient-Reported Outcome Measure

NCT00530049
View directory record Official record
Conditions
Head and Neck Cancer, Psychosocial Effects of Cancer and Its Treatment
Interventions
questionnaire administration, assessment of therapy complications, psychosocial assessment and care, quality-of-life assessment
Other · Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,745 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2021
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Sep 1, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional

Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

NCT07265557
View directory record Official record
Conditions
Orthopaedic Related Pain (Musculoskeletal Pain), Opioid, Pain, Pilot Study
Interventions
Discharge pain medication prescription
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 1, 2026, 9:55 AM EDT
Completed No phase listed Observational

Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions

NCT01845207
View directory record Official record
Conditions
Aortic Stenosis, Cardiac Valve Replacement Complication, Fragility
Interventions
Not listed
Lead sponsor
Jewish General Hospital
Other
Eligibility
70 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
4
States / cities
Boston, Massachusetts • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2016 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Phase 3 Interventional Results available

PeriOperative ISchemic Evaluation-2 Trial

NCT01082874
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
Active Clonidine, Placebo Clonidine, Active ASA, Placebo ASA
Drug
Lead sponsor
Hamilton Health Sciences Corporation
Other
Eligibility
45 Years and older
Enrollment
10,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2016 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Not applicable Interventional Results available

Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures

NCT00556842
View directory record Official record
Conditions
Hip Fractures, Femoral Neck Fractures
Interventions
Total hip arthroplasty, Hemi-arthroplasty
Device
Lead sponsor
McMaster University
Other
Eligibility
50 Years and older
Enrollment
1,495 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Sep 1, 2026, 9:55 AM EDT
Terminated Phase 1 Interventional Results available

Thrombolysis in Pediatric Stroke (TIPS)

NCT01591096
View directory record Official record
Conditions
Stroke
Interventions
Tissue plasminogen activator (Activase®)
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
2 Years to 17 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
13
States / cities
Palo Alto, California • Aurora, Colorado • Boston, Massachusetts + 9 more
Source: ClinicalTrials.gov public record
Updated May 24, 2018 · Synced Sep 1, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional

Pericardiotomy in Cardiac Surgery

NCT06486636
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Flutter, Cardiac Events
Interventions
Left Posterior Pericardiotomy
Procedure
Lead sponsor
Population Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Not applicable Interventional Results available

Fluid Lavage of Open Wounds (FLOW): Pilot Trial

NCT01069315
View directory record Official record
Conditions
Infection, Wound Healing Problem, Nonunion
Interventions
Type of fluid lavage solution, Type of fluid lavage pressure
Procedure
Lead sponsor
McMaster University
Other
Eligibility
Not listed
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
3
States / cities
Columbia, Missouri • Greenville, South Carolina • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2019 · Synced Sep 1, 2026, 9:55 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Bupivacaine Epiphora Trial

NCT03266081
View directory record Official record
Conditions
Epiphora, Ptosis
Interventions
0.75% bupivacaine
Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2022 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Phase 2 Interventional Results available

Optimal Vitamin D3 Supplementation Strategies for Acute Fracture Healing

NCT02786498
View directory record Official record
Conditions
Fracture
Interventions
Vitamin D3, Placebo
Drug · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 50 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 1, 2026, 9:55 AM EDT
Terminated Phase 3 Interventional

Strategies for Transfusion of Platelets (SToP)

NCT00420914
View directory record Official record
Conditions
Thrombocytopenia
Interventions
low dose of 2.25 x 10^11 platelets/transfusion (range 1.5 to 2.9)
Procedure
Lead sponsor
Hamilton Health Sciences Corporation
Other
Eligibility
17 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
2
States / cities
Los Angeles, California • Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 27, 2008 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Phase 2 Interventional

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial

NCT01782755
View directory record Official record
Conditions
Ventilator Associated Pneumonia (VAP), Other Infections, Antibiotic-Associated Diarrhea, C-Difficile, Duration of Mechanical Ventilation, Length of ICU Stay, Length of Hospital Stay, ICU and Hospital Mortality
Interventions
L. rhamnosus GG - Probiotic, Placebo - Microcrystalline Cellulose
Drug · Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
Rochester, Minnesota • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 1, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise

NCT07063732
View directory record Official record
Conditions
High Altitude Hypoxia, Exercise
Interventions
Ketone Monoester (KME), Placebo
Dietary Supplement
Lead sponsor
McMaster University
Other
Eligibility
18 Years to 35 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Bishop, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced Sep 1, 2026, 9:55 AM EDT
Active, not recruiting Not applicable Interventional

Surveillance AFter Extremity Tumor surgerY

NCT03944798
View directory record Official record
Conditions
Soft Tissue Sarcoma, Lung Metastases
Interventions
Frequency: Every 3 Months, Frequency: Every 6 Months, Imaging Modality: Chest Radiograph (CXR), Imaging Modality: Chest CT
Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
16
States / cities
Sacramento, California • Hartford, Connecticut • Gainesville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Sep 1, 2026, 9:55 AM EDT
Terminated Phase 3 Interventional Results available

Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2)

NCT01908751
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Sliding Hip Screw, Cancellous Screws, Vitamin D, Vitamin D Placebo
Procedure · Drug
Lead sponsor
McMaster University
Other
Eligibility
18 Years to 60 Years
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
10
States / cities
Phoenix, Arizona • San Francisco, California • Gainesville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2020 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Not applicable Interventional

Remote Ischemic Preconditioning in Cardiac Surgery Trial

NCT01071265
View directory record Official record
Conditions
Cardiac Surgery
Interventions
Remote Ischemic Preconditioning, Sham
Procedure
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Portland, Maine • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 27, 2015 · Synced Sep 1, 2026, 9:55 AM EDT
Completed Not applicable Interventional Results available

Chalazion Conservative Treatment Trial

NCT01230593
View directory record Official record
Conditions
Chalazion Unspecified Eye, Unspecified Eyelid, Chalazion Left Eye, Unspecified Eyelid, Chalazion Right Eye, Unspecified Eyelid, Chalazion Both Eyes
Interventions
Hot Compress plus Tobramycin Drops and Ointment, Hot compress plus Tobramycin/Dexamethasone Drops and Ointment, Hot Compresses
Drug · Other
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Elmhurst, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Sep 1, 2026, 9:55 AM EDT
Active, not recruiting Not applicable Interventional

A Study for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients

NCT03127631
View directory record Official record
Conditions
Prostate Cancer, Cardiovascular Disease
Interventions
Nutrition, Exercise, Smoking cessation, Statin (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), ACE inhibitor
Behavioral · Drug
Lead sponsor
McMaster University
Other
Eligibility
45 Years and older · Male only
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
4
States / cities
Augusta, Georgia • Kansas City, Kansas • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 1, 2026, 9:55 AM EDT
Recruiting No phase listed Observational

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

NCT05600946
View directory record Official record
Conditions
Cognitive Disorder, Metabolic Disease, Autism Spectrum Disorder
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
2 Years to 40 Years · Male only
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 1, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional

Trial of Social Work Services in Fracture Clinic Setting

NCT06973655
View directory record Official record
Conditions
Orthopaedic Fractures, Socioeconomic Factors
Interventions
Social Work support
Other
Lead sponsor
Sheila Sprague
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 1, 2026, 9:55 AM EDT
Recruiting Not applicable Interventional

The Fourth Left Atrial Appendage Occlusion Study

NCT05963698
View directory record Official record
Conditions
Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
Interventions
WATCHMAN device
Device
Lead sponsor
Hamilton Health Sciences Corporation
Other
Eligibility
18 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
50
States / cities
Birmingham, Alabama • Jonesboro, Arkansas • Fountain Valley, California + 45 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 1, 2026, 9:55 AM EDT